Clinical Observation on 24 Cases of Chronic Obstructive Pulmonary Disease of Stationary Phase Combined with Stable Angina Pectoris with Qi Deficiency-blood Stasis-phlegm Blockade Syndrome: Simultaneous Intervention for Heart and Lung

LIU Yujin; JIA Zhenhua; WANG Junhua; ZHAO Zhenjun; WANG Yali; HEI Dongmei; LI Xiao-jiao; WU Yiling

doi:10.13288/j.11-2166/r.2017.17.012

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Clinical Observation on 24 Cases of Chronic Obstructive Pulmonary Disease of Stationary Phase Combined with Stable Angina Pectoris with Qi Deficiency-blood Stasis-phlegm Blockade Syndrome: Simultaneous Intervention for Heart and Lung

更新时间：2021-11-10

- Clinical Observation on 24 Cases of Chronic Obstructive Pulmonary Disease of Stationary Phase Combined with Stable Angina Pectoris with Qi Deficiency-blood Stasis-phlegm Blockade Syndrome: Simultaneous Intervention for Heart and Lung
- Journal of Traditional Chinese Medicine Vol. 58, Issue 17, Pages: 1482-1486(2017)
- 作者机构：
  
  1. 河北医科大学研究生学院
  2. 河北医科大学附属以岭医院
  3. 河北以岭医药研究院
  4. 石家庄以岭药业股份有限公司
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2017.17.012
  CLC： R259
- Published：2017
- 稿件说明：
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[1]刘玉金,贾振华,王军花,赵振军,王亚丽,黑冬梅,李小佼,吴以岭.心肺同治干预慢性阻塞性肺疾病稳定期合并稳定性心绞痛气虚血瘀痰阻证患者24例临床观察[J].中医杂志,2017,58(17):1482-1486.

LIU Yujin, JIA Zhenhua, WANG Junhua, et al. Clinical Observation on 24 Cases of Chronic Obstructive Pulmonary Disease of Stationary Phase Combined with Stable Angina Pectoris with Qi Deficiency-blood Stasis-phlegm Blockade Syndrome: Simultaneous Intervention for Heart and Lung[J]. Journal of Traditional Chinese Medicine2017, 58(17): 1482-1486.
[1]刘玉金,贾振华,王军花,赵振军,王亚丽,黑冬梅,李小佼,吴以岭.心肺同治干预慢性阻塞性肺疾病稳定期合并稳定性心绞痛气虚血瘀痰阻证患者24例临床观察[J].中医杂志,2017,58(17):1482-1486. DOI： 10.13288/j.11-2166/r.2017.17.012.

LIU Yujin, JIA Zhenhua, WANG Junhua, et al. Clinical Observation on 24 Cases of Chronic Obstructive Pulmonary Disease of Stationary Phase Combined with Stable Angina Pectoris with Qi Deficiency-blood Stasis-phlegm Blockade Syndrome: Simultaneous Intervention for Heart and Lung[J]. Journal of Traditional Chinese Medicine2017, 58(17): 1482-1486. DOI： 10.13288/j.11-2166/r.2017.17.012.

摘要

目的观察心肺同治干预慢性阻塞性肺病（COPD）稳定期合并稳定性心绞痛气虚血瘀痰阻证的临床疗效。方法将96例COPD稳定期合并稳定性心绞痛气虚血瘀痰阻证患者随机分为对照组、橘红片组、通心络组和橘加通组

每组24例。对照组采取西医常规治疗;橘红片组在对照组的基础上加用橘红片3.6 g口服

每日2次;通心络组在对照组的基础上加用通心络胶囊1.04 g口服

每日3次;橘加通组在对照组的基础上加用橘红片和通心络胶囊

服法同上。各组疗程均为8周。比较治疗前后咳嗽、咯痰、呼吸困难评分及圣乔治呼吸问卷（SGRQ）评分

心绞痛发作次数、疼痛持续时间、硝酸甘油用量

肺功能[包括第一秒用力呼气容积（FEV1）、用力肺活量（FVC）]及血清C反应蛋白（CRP）、白细胞介素1β（IL-1β）、白细胞介素10（IL-10）水平。结果本组治疗前比较

橘红片组、通心络组和橘加通组可不同程度降低咳嗽、咯痰、呼吸困难评分及SGRQ评分

升高FEV1、FVC

降低心绞痛发作次数、疼痛持续时间、硝酸甘油用量及血清CRP、IL-1β、IL-10水平

并且橘加通组在部分指标上效果优于橘红片组和通心络组（P<0.05或P<0.01）。结论心肺同治法能改善COPD稳定期合并稳定性心绞痛气虚血瘀痰阻证患者临床症状、肺功能

抑制慢性持续性炎症反应可能是其重要机制之一。

Abstract

Objective To examine the clinical effect of simultaneous intervention for heart and lung on chronic obstructive pulmonary disease（ COPD） of stationary phase combined with stable angina pectoris with Qi deficiencyblood stasis-phlegm blockade syndrome. Methods Ninety-six COPD stationary phase combined with stable angina pectoris patients with Qi deficiency-blood stasis-phlegm blockade syndrome were randomized into control group

Juhong [Exocarpium Citri Rubrum]tablet group

the Tongxinluo（通心络） group and the Ju&Tong group

24 cases in each group. The control group was given western medicine routine therapy. In addition to the treatment of the control group

Juhong tablet 3. 6 g was given to the Juhong tablet group orally

twice each day; Tongxinluo capsule 1. 04 g was given to the Tongxinluo group orally

three times each day; Juhong tablet and Tongxinluo capsule were given to the Ju&Tong group. Each group was treated for 8 weeks. The following intems were compared before and after treatment including the scores of cough

cough up phlegm

dyspnea and St. George’ s Respiratory Questionnaire（ SGRQ）

anginal attacks

durante dolors

nitroglycerin consumption

pulmonary function [including forced expiratory volume in one second（ FEV1） and forced vital capacity（ FVC） ]

as well as the levels of serum C reactive protein（ CRP）

interleukin 1β（ IL-1β） and interleukin 10（ IL-10）. Results After treatment

the scores of cough

cough up phlegm

dyspnea and SGRQ decreased in the Juhong tablet group

the Tongxinluo group and the Ju&Tong group. FEV1 and FVC increased. Anginal attacks

durante dolors

nitroglycerin consumption

as well as the levels of serum CRP

IL-1βand IL-10 decreased. Moreover

the effect of certain indexes in the Ju&Tong group was superior to those in the Juhong tablet group and the Tongxinluo group（ P < 0. 05 or P < 0. 01）. Conclusion Simultaneous intervention for heart and lung might improve clinical symptoms and pulmonary function of COPD stationary phase combined with stable angina pectoris with Qi deficiency-blood stasis-phlegm blockade syndrome patients. Inhibiting chronic persistent inflammation might be one of the important mechanisms.

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Related Institution

Chengdu Seventh People's Hospital

Affiliated Hospital of Chengdu University of Traditional Chinese Medicine

Wangjing Hospital,China Academy of Chinese Medical Sciences

The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine

Tianjin University of Traditional Chinese Medicine

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