Objective To investigate the effect of externally used Tongluo Sanjie Gel （通络散结凝胶） on bone cancer pain.Methods Thirty rats were randomized into sham operation group

Chinese medicine group and placebo group

with 10 mice in each group.Tumor cells were injected to establish rat bone cancer pain model in Chinese medicine group and placebo group.The rats in sham operation group and placebo group were externally administered blank gel on the model side of the tibia

while Tongluo Sanjie Gel was used in the treatment group.Each group was given the gel twice a day respectively on 8: 00 and 20: 00

with 1g gel each time.The treatment lasted for 21 days.The general condition

weight

spontaneous pain score

thermal pain

mechanical pain

injured limb bearing and tibial bone mineral density （BMD） were observed.Results Compared with those of the sham group

the activity of the placebo group and the Chinese medicine group decreased gradually

the hairiness decreased and the body weight decreased.The bone weight

paw withdrawal thermal latency （PWTL） and 50% paw withdrawal mechanical threshold （PWMT）

injured limb bearing and tibial BMD in the Chinese medicine group was significantly higher than those in the placebo group from day 16 to day 21 （P < 0.05 or P < 0.01）.The spontaneous pain score in the Chinese medicine group was lower than that in the placebo group from day 16 to day 20 （P < 0.01）

but the scores on day 10

day 16 and day 20 were higher than those in the sham operation group （P < 0.01）.Conclusion Externally used Tongluo Sanjie Gel can significantly improve the general condition

weight

spontaneous pain

mechanical pain and thermal pain

injured limb bearing and BMD of rats with bone cancer pain.