Effect of Qingjin Huazhuo Fang（ 清金化浊方） on Antibiotic Treatment Course in Patients with Acute Exacerbation of Infectious Chronic Obstructive Pulmonary Disease

WU Wei; WANG Bin; WANG Wei; LIU Huimei; LAI Xue; GAO Feng

doi:10.13288/j.11-2166/r.2017.20.014

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Effect of Qingjin Huazhuo Fang（清金化浊方） on Antibiotic Treatment Course in Patients with Acute Exacerbation of Infectious Chronic Obstructive Pulmonary Disease

更新时间：2021-11-10

- Effect of Qingjin Huazhuo Fang（清金化浊方） on Antibiotic Treatment Course in Patients with Acute Exacerbation of Infectious Chronic Obstructive Pulmonary Disease
- Journal of Traditional Chinese Medicine Vol. 58, Issue 20, Pages: 1764-1767(2017)
- 作者机构：
  
  中国中医科学院望京医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2017.20.014
  CLC： R259
- Published：2017
- 稿件说明：
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[1]吴蔚,王彬,汪伟,刘惠梅,来薛,高峰.清金化浊方对感染性慢性阻塞性肺疾病急性加重患者抗生素疗程的影响[J].中医杂志,2017,58(20):1764-1767.

WU Wei, WANG Bin, WANG Wei, et al. Effect of Qingjin Huazhuo Fang（清金化浊方） on Antibiotic Treatment Course in Patients with Acute Exacerbation of Infectious Chronic Obstructive Pulmonary Disease[J]. Journal of Traditional Chinese Medicine2017, 58(20): 1764-1767.
[1]吴蔚,王彬,汪伟,刘惠梅,来薛,高峰.清金化浊方对感染性慢性阻塞性肺疾病急性加重患者抗生素疗程的影响[J].中医杂志,2017,58(20):1764-1767. DOI： 10.13288/j.11-2166/r.2017.20.014.

WU Wei, WANG Bin, WANG Wei, et al. Effect of Qingjin Huazhuo Fang（清金化浊方） on Antibiotic Treatment Course in Patients with Acute Exacerbation of Infectious Chronic Obstructive Pulmonary Disease[J]. Journal of Traditional Chinese Medicine2017, 58(20): 1764-1767. DOI： 10.13288/j.11-2166/r.2017.20.014.

摘要

目的观察清金化浊方对感染性慢性阻塞性肺疾病急性加重（AECOPD）患者抗生素治疗疗程的影响。方法采用前瞻性、随机、平行对照的研究方法

将40例急性加重病程≤1周的感染性AECOPD（Ⅱ级）住院患者随机分为治疗组和对照组各20例。对照组采用AECOPD常规西医治疗方案

治疗组在此基础上加用清金化浊方中药口服

每日1剂

疗程10天。以治疗后呼吸困难严重程度较治疗前改善≥1个级别、无脓性痰、体温正常24 h以上、白细胞计数（WBC）≤10×10

/L、中性粒细胞百分比（NEUT%）≤75%、C反应蛋白（CRP）≤20 mg/L、降钙素原（PCT）≤0.25μg/L为停用抗生素指征

观察各组抗生素疗程改善情况。结果治疗组患者呼吸困难、痰液性状改善时间及WBC、NEUT%、CRP恢复时间均较对照组缩短（P

0.05）

治疗组抗生素疗程较对照组缩短显著（P

0.05）。结论清金化浊方可有效减轻细菌感染诱发的AECOPD患者炎性反应

缩短抗生素疗程。

Abstract

Objective To observe the effect of Qingjin Huazhuo Fang（清金化浊方

QHF） on antibiotic treatment course in patients with acute exacerbation of infectious chronic obstructive pulmonary disease（ AECOPD）.Methods As a prospective

randomized and parallel controlled study

40 patients with acute AECOPD（ grade II）whose disease course was less than 1 week were randomized into treatment group and control group

20 in each group.Both groups were treated with conventional western medicine treatment for AECOPD. In addition to this

the treatment group was also treated with orally administered QHF with one dose per day. The treatment was lasted for 10 days. The improvement of the treatment course of antibiotics in each group were observed with the following indications to stop antibiotics: the severity of dyspnea improving by ≥1 level after treatment

no purulent sputum

body temperature keeping normal for more than 24 hours

white blood cell count（ WBC） ≤ 10 × 109/L

neutrophil percentage（ NEUT%） ≤75%

C-reactive protein（ CRP） ≤20 mg/L and procalcitonin（ PCT） ≤0. 25 μg/L. Results Time for the improvement of dyspnea and sputum traits and time for the recovery of WBC

NEUT% and CRP in the treatment group were significantly shorter than those in the control group（ P < 0. 05）

and the antibiotic treatment course in the treatment group was significantly shorter than that in the control group（ P < 0. 05）. Conclusion QHF could effectively reduce the inflammatory reaction of the bacterial infection induced AECOPD and shorten the antibiotic treatment course.

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