Objective To observe the protective effect of Shenrong Body Lotion（ 参茸护肤乳

SBL） on skin aging and its potential mechanism. Methods By drawing lots

71 mice were divided into a blank group

a model group

a matrix group

a positive control group and Shenrong high

medium and low dose groups

with 9 mice in each group. D-galactose was injected subcutaneously to establish the skin aging model in all groups except for the blank group. After modeling

the matrix group was applied the body lotion matrix for skin care

the positive control group was given Revitalift Anti-Wrinkle Emulsion

while the Shenrong high

medium and low dose groups were respectively given body lotion containing 12% Renshen [人参 Ginseng Radix Et Rhizoma] extract and 11% Lurong [鹿茸 Cervi Cornu Pantotrichum]

collagen peptide

7% Renshen extract and 5% Lurong collagen peptide

and 3% Renshen extract and 2% Lurong collagen peptide. The dose was 1 mg/cm

2

for all groups

and the treatment period was 42 days. The contents of water

hyaluronic acid

hydroxyproline

and malondialdehyde（ MDA）

and the activity of glutathione peroxidase（ GSH-Px） and superoxide dismutase（ SOD） in the skin tissues were observed. There were also another 8 mice subjected to acute multiple skin irritation test to observe the irritation of SBL for the skin of mice.Results SBL was safe and non-irritating for skin. The content of water

hyaluronic acid and hydroxyproline decreased

and the activity of GSH-Px and SOD also decreased while the content of MDA increased in the model group（ P

<

0. 01）. After the application of high dose SBL

the contents of water

hyaluronic acid and hydroxyproline and the activity of SOD and GSH-Px in the skin significantly increased while the content of MDA significantly decreased（ P

<

0. 05 or P

<

0. 01）

and the effect was quite similar to that of Revitalift Anti-Wrinkle Emulsion.Conclusion SBL seems to have significant effect on improving skin aging

and the potential mechanism might be improving the content of skin moisture

hyaluronic acid

and hydroxyproline

increasing the activity of SOD and GSH-Px

and reducing MDA content in skin aging mice.