Objective To explore the possible mechanism of acupoint application in treating allergic asthma.Methods Forty Wistar rats were randomized into a blank group

a model group

an application 2 h group

and an application 4 h group

with 10 in each group. Rats in all groups were made allergic asthma models by suspension of chicken ovalbumin（ OVA） and normal saline multi-point subcutaneous injection and by aerosol inhalation sensitization

except those in the blank group. From the 15 th day after modeling

the blank group and the model group were fed as usual. The application 2 h group and the application 4 h group were given acupoint application at rats’ "Feishu"（ BL 13）

"Pishu"（ BL 20） and"Shenshu"（ BL 23） for 2 h and 4 h

respectively once every 2 days

for 7 times.Rats’ latent period of inducing asthma and total duration of seizures in each group were examined. Rats’ serum levels of transforming growth factor β1（ TGF-β1） and urotensin Ⅱ（ UⅡ） were detected with Enzyme Linked Immunosorbent Assay（ ELISA） method. Pathological changes of bronchus and lung tissue of rats were examined with hematoxylin and eosin（ HE） stain. Results Compared with those in the model group

the latent period of inducing asthma extended

the total duration of seizures reduced

and the serum levels of TGF-β1 and UⅡ decreased（ P < 0. 01）

and also the pathological changes such as unclear structure of bronchus and lung

bronchial mucosal edema

hyperemia and airway wall thickening

etc. were obviously improved in the application 2 h group and the application 4 h group. There were no significant differences in latent period of inducing asthma

total duration of seizures

and serum levels of TGF-β1 and UⅡ between the application 4 h group and the application 2 h group（ P > 0. 05）. Conclusion Acupoint application might reduce the serum levels of TGF-β1 and UⅡ to improve airway remodeling

which might be one of the mechanisms in treating allergic asthma.