Objective To observe the clinical effect of Qingdan Hewei Granules（ 清胆和胃颗粒） on bile reflux gastritis. Methods Randomly divided 93 patients with bile reflux gastritis into treatment group with 47 cases

and control group with 46 cases. The treatment group was given Qingdan Hewei Granules orally

10 g each time

twice a day

2 h after meals; the control group was given Compound Bismuth Aluminate Granules orally

1. 3 g each time

3 times a day

30 min before meals. Both groups were treated for 4 weeks. Before and after treatment

graded the Chinese medicine symptoms

detected pathological tissue of gastric mucosa

and evaluated the curative effect of Chinese medicine symptoms after treatment. Results After treatment

the Chinese medicine symptom scores including bloating

stomach pain

acid regurgitation

heartburn

anorexia

bitter taste

ozostomia

vexation and irritability

short yellow urine

and constipation of the treatment group patients were significantly lower than those before treatment

and symptom scores of bloating

anorexia

bitter taste

ozostomia

vexation and irritability were significantly lower than the control group（ P < 0. 05）. The total effective rate of curative effect on Chinese medicine symptoms in the treatment group was 87. 2%

which was significantly higher than that of the control group of 80. 4%（ P < 0. 05）.The level of lamina propria

vasodilatation and inflammation of patients reexamining gastroscopy in both groups（ 32 cases in the treatment group

29 cases in the control group） all decreased after treatment compared with those before treatment

and the treatment group decreased more significantly than the control group（ P < 0. 05）. Conclusion Qingdan Hewei Granules in the treatment of bile reflux gastritis could not only improve symptoms

but also reduce local inflammatory response.