Objective To find the long non coding RNA（ lncRNA） related to 2 diabetes with kidney-yin deficiency syndrome and to explore the regulatory mechanism. Methods Gene expression profiles detection was made by lncRNA/mRNA chip to test the peripheral blood of 6 patients with type 2 diabetes with kidney-yin deficiency syndrome and 4 healthy adults. The differential lncRNA was obtained by comparing data of two groups. Prediction of target genes was made in differential lncRNA. Pooled analysis was conducted on the target genes and differential lncRNA to find lncRNA which might be related to onset of type 2 diabetes with kidney-yin deficiency syndrome. Results Two hundred and seventy-five differential lncRNAs were screened out. Among them

there were 217 up-regulating lncRNAs and 58 down-regulating lncRNAs. By cis-acting prediction

there were 161 related differential lncRNAs. By trans-acting prediction

there were 107 related differential lncRNAs. It was found by comparing with differential RNA data that target genes expression levels changed in 7 lncRNAs. Conclusion lncRNA AF116618 and HMlinc RNA880 seem to have close relation to onset and development of type 2 diabetes with kidney-yin deficiency syndrome

and they might be new diagnostic markers and drug targets of type 2 diabetes with kidney-yin deficiency syndrome.