Objective To observe the effect of Chinese medicine Fangxiang Waifu Fang（ 芳香外敷方） on bone metastasis of lung cancer. Methods Established lung cancer with bone metastatic mice models by intra-femur injection human lung adenocarcinoma A549 cells transfected with green fluorescent protein. After successful modeling

mice were randomized into two groups with 10 in each group. Chinese medicine external application group was given Fangxiang Waifu Fang 0. 5 g/（ kg·d） local external application

once every day from 7 th day to 21 st day after modeling

while the zoledronic acid group was given zoledronic acid injection 30 μg/（ kg·d） by intraperitoneal injection on the 7 th

10 th

14 th and 19 th day after modeling

and the model group（ normal saline local external application

0. 5 ml/mouse

once every day）

n = 10. The sham operation group was given normal saline local external application

0. 5 ml/mouse

once every day. Body weight was measured in each group on the modeling day

on the 3 rd

7 th

11 th

14 th

17 th and 21 st day after modeling. Tumor area and metastasis were examined by FluorVivo image-forming system. Tumor weight was measured on the 21 st day of modeling. Results The difference of mice body weight in each group at different time was not significant（ P

>

0. 05）. No metastasis of other parts and organs was observed in mice in each group. On the 21 st day

mice tumor area was（ 12. 32 ± 6. 94） mm

2

in the Chinese medicine external application group

which was smaller than（ 23. 91 ± 9. 86） mm

2

in the model group and（ 17. 16 ±7. 37） mm

2

in the zoledronic acid group（ P

<

0. 05）. Moreover

tumor weight was also less than that in the model group（ P

<

0. 01）. Compared with the zoledronic acid group and the model group

the difference of tumor area and tumor weight was not significant（ P

>

0. 05）. Conclusion The Fangxiang Waifu Fang could inhibit the tumor growth of lung cancer bone metastasis.