Objective To observe the effect of Tibetan medicine Qishiwei Zhenzhu Wan（ 七 十味珍珠丸） on behavior of parkinson’s disease（ PD） model rats. Methods Forty-eight rats were randomized into normal group

model group

madopar group

and Tibetan medicine low

median and high dose groups（ n = 8）. Rats except for the normal group were made PD rat models by single point injection of 6-hydroxy dopamine in the right striatum. After modeling

the madopar group was given madopar 50 mg/kg by gavage respectively. The Tibetan medicine low

median and high dose groups were given Tibetan medicine Qishiwei Zhenzhu Wan solution 90

180 and 360 mg/kg by gavage respectively. The model group and the normal group were given equivalent normal saline by gavage. Rats in each group were gavaged once every day for 4 weeks. After intervention

rotational behavior experiment

balancing rod experiment and body torsion pendulum experiment were carried out. Results Compared with the normal group

in rotational behavior experiment

rats’ number of uninjured side rotation increased in the model group

and the latency time and total layout time were lengthened in balancing rod experiment. In body torsion pendulum experiment

uninjured side torsion pendulum frequency increased（ P < 0. 05 or P < 0. 01）. Compared with the model group

the latency time in the medication groups was shortened in balancing rod experiment; total layout time in the Tibetan medicine low and high dose groups was shortened. In body torsion pendulum experiment

rats’ uninjured side torsion pendulum frequency in the Tibetan medicine low and high dose groups was lower than that in the model group（ P < 0. 05 or P < 0. 01）. Compared the model group with all medication groups

in rotational behavior experiment

the difference of rats rotation number was not significant（ P > 0. 05）. Conclusion The Tibetan medicine Qishiwei Zhenzhu Wan might improve PD rats’ motor function.