Objective To explore the potential mechanism of Jiedu Quyu Ziyin Decoction（ 解毒祛瘀滋阴 方

JQZD） in treating systemic lupus erythematosus. Methods Thirty MRL/lpr lupus mice were randomized into Chinese medicine（ CM） group

Western medicine（ WM） group and the model group

with 10 mice in each group

and the other 10 C57 BL/6 mice were set as the control group. CM group was given 0. 5 g/ml of JQZD by gavage

WM group was given 0. 5 mg/ml of prednisone acetate tablets suspension by gavage

while the model group and the control group were given distilled water orally. All interventions were given 0. 01 ml/g once a day

for 12 weeks. After the intervention

General statuses of fur

activity and superficial lymph nodes of mice were observed. Serum levels of IL-4 and IFN-γ were detected. The pathological changes of kidney were observed with HE staining. The expression levels of MeCP2 m RNA and protein in CD4

+

T cells in mice spleen were detected. Results Compared with those in the model group

the pathological changes of kidney significantly improved

the serum levels of IL-4 and IFN-γ decreased

and the expressions of MeCP2 m RNA and protein significantly increased in CM group（ P

<

0. 05 or P

<

0. 01）. The expressions of MeCP2 protein and m RNA in CM group were significantly higher than that in WM group（ P

<

0. 05 or P

<

0. 01）. Conclusion JQZD may inhibit systemic lupus erythematosus through the activation of MeCP2 signaling pathway.