Objective To explore the effect of Jianpi Yizhi Capsule（ 健脾益智胶囊） combined with enriched rehabilitation training on the motor function of rats with ischemic stroke and its possible mechanism. Methods Seventy-two Sprague Dawley rats were randomly divided into a sham operation group

a model group

a rehabilitation group and a comprehensive rehabilitation group

with 18 rats in each group. All the groups except the sham operation group were treated by thermocoagulation on middle cerebral artery to replicate the rat model of ischemic stroke. Since the third day after successful modeling

both the rehabilitation group and the comprehensive rehabilitation group were given enriched rehabilitation training for treatment

once a day; and the comprehensive rehabilitation group was given 15 ml/（ kg·d） of Jianpi Yizhi Capsule suspension once a day in addition. Conducted Longa score

balance beam walking test score and walking rod test score were evaluated

and the expression of nerve growth associated protein 43（ GAP-43） in periinfarction cortex of brain tissue was detected in each group on the 7 th

14 th and 21 st days after modeling

respectively. Results At each time point

the Longa score

the balance beam walking test score and the walking rod test score in the comprehensive rehabilitation group were all lower than those in the model group. The number of GAP-43 positive cells in periinfarction cortex of brain tissue of rats in the comprehensive rehabilitation group increased compared with that in the model group

and it was better than that in the rehabilitation group（ P <0. 05 or P < 0. 01）. Conclusion Jianpi Yizhi Capsule combined with enriched rehabilitation training could effectively promote the recovery of neurological function in rats with ischemic stroke

and its mechanism may be related to the increase of GAP-43 expression in periinfarction cortex of rat brain tissue.