Leigongteng [Tripterygium Wilfordii Hook. f.（TWHF） ]

as an effective immunosuppressive agent

is most commonly used in the treatment of various rheumatic immune diseases

but also is one of the herbs with most reported adverse reactions. The author put forward the theory of "heterogeneous restriction"based on the traditional Chinese medicine compatibility principle

which is that the toxicity of toxic herbs can be reduced or removed by regulating and restraining the toxicity through compatibility with Chinese herbs with different properties

flavors and actions. Based on a series of studies on"heterogeneous restriction"theory

the modern biological mechanism of detoxicity effect of the compound prescription of TWHF was explored on the basis of clinical practice

and the scientific connotation of "heterogeneous restriction"theory was deeply interpreted

providing ideas for the clinical safe and rational application of toxic Chinese herbs such as TWHF.