YAN Shiyun’s experience in clinical application of cream formula was summarized. It was proposed that under the guidance of the concept of "harmony"

the principles of the prescription for cream formula should be balanced in supplementing and drainage

and unblocking and supplementing

and mutual restriction of herb nature

interdependence and impartiality. Its clinical thinking is characterized by starting from the syndrome and grasping the development and changes in the pathogenesis

flexible response. The specific applications of cream formula should be closely linked to the pathogenesis and fully grasp.