Objective To explore the possible mechanism of Qidan Fugan Granules（ 芪丹复感颗粒） in treating pediatric recurrent respiratory tract infection. Methods Sixty Kunming mice were randomized into blank control group

model group

pidotimod group

Qidan Fugan Granules of high

medium and low dose groups

with 10 mice in each. Except for the blank control group

mice in the other groups were sensitized with ovalbumin and aerosolized to prepare a model of respiratory mucosal immunity. After modeling

the high

medium

and low doses of Qidan Fugan Granules group were given 0. 324

0. 162

and 0. 081 g/10 g

respectively

while those in the pidotimod group were given 0. 024 g/10 g pidotimod Gandudu. The blank control group was given intragastric administration of 0. 1 ml/10 g saline once daily. After 2 weeks of gavage

the spleen index

thymus index

and gastrointestinal propulsive rate of each group of mice were calculated

and the content of secretory immunoglobulin A（ s Ig A） was determined.Results The spleen index

thymus index

gastrointestinal propulsion rate

and s Ig A in the model group were lower than those in the control group（ P < 0. 05 or P < 0. 01）; the spleens index

thymus index

gastrointestinal propulsion rate

and s Ig A of the mice in the high-

middle-

and low-dose groups of Piedemold and Qidan Fugan Granules groups were all higher than those in the model group（ P < 0. 05）. There were no significant differences in the indexes among the high

middle

and low doses of Qidan Fugan Granules group（ P > 0. 05）. Conclusion Qidan Fugan Granules can promote intestinal peristalsis in mice with low respiratory mucosal immunity and increase the s Ig A level in intestinal fluids

which may be one of the mechanisms for the treatment of repeated respiratory infections in children.