Objective To evaluate the clinical practice guideline of sepsis published in recent 5 years in all countries to provide reference for future research and formulation of clinical practice guidelines. Methods Dates for the published guidelines on clinical practice of sepsis and related materials ranged from 2013 to 2017 were searched in Pub Med database

CNKI

Wanfang database

Medline

Embase and Institutes. The Appraisal of Guidelines for Research and Evaluation Ⅱ（ AGREE Ⅱ） instrument was used to evaluate the methodological quality of the included sepsis clinical practice guideline

and the contents of assessments included scope and purpose

stakeholder involvement

rigour of development

clarity of presentation

applicability

editorial independence

and overall evaluation. Results A total of eight sepsis clinical practice guidelines were included. The evaluation results of the sepsis clinical practice guidelines showed that the domain of clarity of presentation had the highest average score: 82. 29%

followed by the domain of scope and purpose

with an average score of 70. 95%. The average score of the domain of rigour of development was 52. 99%. The average score of stakeholder involvement was 46. 53%. The average score of editorial independence was 45. 31%; while the domain of applicability was the lowest score 44. 27%. The overall guideline assessments of eight clinical guidelines were 50. 00% to 88. 89%

with recommended for all results.Conclusion The current clinical practice guidelines for sepsis have lower methodological quality in the three domians of stakeholder involvement

applicability

and editorial independence. In the future

guidelines for the development of clinical practice that conforms to China’ s national conditions should be formulated in accordance with the normative guidelines. At the same time

attention should also be given to the promotion and application of the guidelines.