Objective To evaluate the effectiveness and safety of Bushen Huoxue（ 补肾活血） Chinese medicine in the treatment of premature ovarian failure（ POF）. Methods Databases of Pub Med

Embase and Cochrane Library

Chinese National Knowledge Infrastructure（ CNKI）

Wan Fang

VIP and China Biology Medicine（ CBM）were searched for randomized controlled trial（ RCT） on Bushen Huoxue Chinese medicine in treating POF from inception to 31 October 2017. Meta-analysis was carried out for the clinical total effective rate

symptom integral

menstruation recovery rate and adverse effect of patients with POF after the treatment. Risk of bias evaluation tools was adopted to conduct quality evaluation. Meta-analysis on outcome indicator was performed by Rev Man Version 5. 3 Software.Results A total of 12 RCTs containing 824 patients were included. Meta-analysis indicated that Bushen Huoxue Chinese medicine had significant advantages in the improvement of total effective rate [RR = 1. 12

95% CI（ 1. 03

1. 21）

P = 0. 009]

menstruation recovery rate [RR = 1. 15

95% CI（ 1. 05

1. 26）

P = 0. 003 ]

symptom integral improvement [WMD =-2. 55

95% CI（-3. 26

-1. 85）

P < 0. 001] and adverse reaction rate [RR =0. 25

95% CI（ 0. 12

0. 53）

P = 0. 0003]. Conclusions Bushen Huoxue Chinese medicine is safe and effective in treating POF. Due to the low quality of the included literature

more high-quality

large-sample clinical trials are needed for further confirmation.