Objective To investigate the possible action mechanism of Yangxue Huoxue Jiedu Fang（养血活血解毒方

YXHXJDF） in the treatment of psoriasis. Methods YXHXJDF was divided into herbs of nourishing blood and activating blood（YXHXF）

and herbs of detoxification（JDF）. Eighty Wistar rats were randomly divided into the blank group

YXHXJDF group

YXHXF group

and JDF group

with 20 rats in each group. The YXHXJDF group

YXHXF group

and JDF group were given the corresponding drugs 10. 18

6. 17

4. 01 g/（kg·d） for intragastric administration

and the blank group was given 4 ml distilled water for 4 days. The drug-containing serum was prepared. Human dermal microvascular endothelial cells（HDMEC） were divided into blank group

model group

YXHXJDF group

YXHXF group

and JDF group. Except the blank group

the other groups used phorbol ester to induce cell activation. At the same time

10% drug-containing serum of the corresponding drug was added for 24 hours. The endothelial cell proliferation

migration

lumen formation

and the expressions of vascular endothelial growth factor（VEGF）

vascular endothelial growth factor receptor（VEGFR）

extracellular regulated protein kinase1（ERK1）

extracellular regulation protein kinase 2（ERK2） mRNA expression were detected. The expression of VEGF/VEGFR pathway and extracellular regulated protein kinases/nuclear factor-kappa（ERK/NF-κB） pathway protein were detected. Results Compared with the blank group

the cell proliferation

migration cell number

lumen formation number

VEGF

VEGFR

ERK2 mRNA and VEGF/p-VEGFR pathway

ERK/NF-κB pathway related protein expressions in the model group were increased（P < 0. 01）. Compared with the model group

cell proliferation

migration cell number

VEGF

VEGFR mRNA expression and p-ERK1

p-EKR2

p-NF-κB p65 protein expressions in the YXHXJDF group and JDF group were decreased

and the expression of VEGF and p-VEGFR protein in the YXHXJDF group was decreased. The cell proliferation and ERK2 mRNA expression in the YXHXJDF group were lower than those in the JDF group（P < 0. 05 or P < 0. 01）. Conclusion YXHXJDF can regulate the expression of angiogenic factor VEGF and its receptor by interfering with ERK/NF-κB pathway

so as to play a therapeutic role in the pathological process of angiogenesis of psoriasis

and the YXHXJDF has the best effects. Its YXHXF components have no effect on the proliferation of endothelial cells.