Objective To observe the effect of Meliorated Renal Failure Decoction（肾衰Ⅱ号方

MRFD） combine with western medicine on primary chronic kidney disease（CKD） 3 or 4 stage patients with spleen and kidney qi deficiency

dampness retention and stasis obstruction syndrome. Methods A total of 88 cases of primary CKD 3 or4 stage of spleen and kidney qi deficiency and dampness retention and stasis obstruction syndrome were randomly divided into treatment group of 44 cases and control group of 44 cases. Patients in both groups were given long term western medicine treatment

respectively add MRFD to treatment group

and uremic clearance granules to control group for continuous 6 months. Serum creatinine（SCr）

blood urea nitrogen（BUN）

uric acid（UA）

24-hour urinary protein quantity（24 h Upro）

and hemoglobin（Hb） were detected before and after the treatment. Ultrasonic detection and measurement was used to detect radiography of right renal medulla（AT

PT

PI

A

AUC

TIC）.Clinical symptoms of traditional Chinese medicine were observed to evaluate the symptoms of traditional Chinese medicine and clinical efficacy after treatment. Results The total effective rate of the treatment group was 82. 92%

which was higher than 60. 00% of the control group（P < 0. 05）. In the treatment group

the total effective rate of shortness of breath

laziness to speak

little intake of food

poor appetite

abdominal distension

limb numbness

greasy and sticky mouth

fatigue

weakness waist and knees

nausea and vomiting

low back pain

dull complexion were higher than the control group（P < 0. 05 or P < 0. 01）. Compared with before treatment

SCr

BUN

UA and24 h UPro were significantly decreased in the treatment group at 2

4

and 6 months

and GFR and Hb after 4 and 6 months’ treatment were significantly increased（P < 0. 05 or P < 0. 01）. The control group had a significant decrease in SCr and 24 h UPro at 6 months of treatment

and the GFR was significantly increased at 4 and 6 months of treatment（P < 0. 05 or P < 0. 01）

and the BUN in the treatment group was significantly lower than that in the control group at6 months

and Hb was significantly higher than the control group（P < 0. 05）. Compared with before treatment

the cortex and medullary renal blood perfusion quantitative parameters AT

PT

A

AUC of treatment group were decreased after treatment

and PI increased（P < 0. 01）. The medullary PT

AUC of control group decreased（P <0. 05）. And the cortex AT

PT

A

medullary AT

PT of treatment group was smaller than the control group after treatment（P < 0. 05 or P < 0. 01）. Conclusion Meliorated Renal Failure Decoction combined with western medicine in the treatment of primary CKD 3 or 4 stage patients with spleen and kidney qi deficiency and dampness and phlegm obstruction syndrome is effective

which can improve the symptoms of traditional Chinese medicine

reduce the 24-hour proteinuria quantification

improve anemia and increase renal blood flow.