Objective To study the clinical efficacy of integrative Kui Jieping Formula（溃结平方） and western medicine in the treatment of patients with mild and moderate ulcerative colitis at the active stage. Methods A total of 200 patients with mild and moderate ulcerative colitis at the active stage were divided into observation group（100 cases） and control group（100 cases） according to their willingness to accept traditional Chinese medicine treatment.The control group was given conventional western medicine therapy

and the observation group was added Kui Jieping Formula by oral administration on the basis of control group

one formula each day. Baron endoscope score of ulcerative colitis

main symptom scores including diarrhea

abdominal pain

abdominal distension

bloody purulent stool

tenesmus and burning sensation in anus were evaluated before and after treatment. The inflammation and immunological index including serum c-reactive protein（CRP）

interleukin 10（IL-10）

Immunoglobulin G（Ig G） and complement C3 were detected. The efficacy on ulcerative colitis and main syndromes after the treatment was determined. Adverse reactions during the study were observed. Results Baron endoscope score

main symptom score and serum CRP

IL-10 and complement C3 in both groups were declined after the treatment

and the level of IL-10 was increased（P < 0. 05）. Baron endoscope score

main symptom score

and the level of CRP

Ig G

complement C3 in serum in observation group was lower than the control group after the treatment

while the level of IL-10 was higher than the control group（P < 0. 05）. The total effective rate in treating ulcerative colitis and main symptoms of the observation group were all 96. 0%

while 76. 0% 、80. 0% in control group. The results in observation group were all superior to the control group（P < 0. 05）. The incidence rate of adverse reactions during the treatment in was 4. 0%in the observation group

and 11. 0% in the control group（P < 0. 01）. Conclusion The efficacy of Kui Jieping Formula combined with western medicine in the treatment of patients with mild and moderate ulcerative colitis at the active stage was better than the western medicine alone

with good safety.