Objective To evaluate the clinical efficacy of Jiawei Xuefu Zhuyu Decoction（ 加味血府逐瘀汤） combined with rivaroxaban in preventing deep venous thrombosis（ DVT） after total knee replacement（ TKA） of patients with knee osteoarthritis. Methods A total of 105 patients were randomly divided into Chinese medicine group（ 35 patients）

western medicine group（ 35 patients） and integrated Chinese and western medicine group（ 35 patients）.All patients in each group accepted pain and rehabilitation management and anti-infective therapy after the surgery.Jiawei Xuefu Zhuyu Decoction by oral administration was given to Chinese medicine group at the 1 st day after the surgery

10 mg rivaroxaban by oral administration to western medicine group

once every night. Jiawei Xuefu Zhuyu Decoction combined with rivaroxaban by oral administration was given to integrated Chinese and western medicine group. All groups were treated for 14 days continuously. The condition of DVT

plasma D-dimer

VAS score

range of movement（ ROM） and traditional Chinese medicine（ TCM） syndrome score were observed before the surgery and on the 3 rd

7 th

14 th day after the surgery. And the postoperative wound healing and complications were observed.Results The level of plasma D-dimer in three groups on the 3 rd

7 th

14 th day after the surgery were all significantly higher than before the surgery（ P < 0. 05）

and D-dimer level of the integrated Chinese and western medicine group on the 3 rd day after the surgery was significantly lower than that of the other 2 groups（ P < 0. 05）. VAS score in each group on the 3 rd

7 th

14 th day after the surgery were all lower than before the surgery（ P < 0. 05） and the score of integrated Chinese and western medicine group in 14 days after the surgery was obviously lower than that of the other groups（ P < 0. 05）. After surgery the TCM syndrome scores in all groups were significantly lower than those before the surgery（ P < 0. 05）

and the score in integrated Chinese and western medicine group was significantly lower than Chinese medicine group and western medicine group in 14 days after the surgery（ P < 0. 05）. The ROM score in 14 days after the surgery in all groups were significantly higher than that before the surgery（ P < 0. 05）. The swelling rate of the integrated Chinese and western medicine group was lower than that of the Chinese medicine group and western medicine group in 14 days after the surgery

and the rate of integrated Chinese and western medicine group was lower than that of the western medicine group（ P < 0. 05）. Conclusion The combination of Jiawei Xuefu Zhuyu Decoction and rivaroxaban is effective in preventing DVT

and is helpful to wound healing.