Effects of Yizhi Ningshen Granules（益智宁神颗粒） on Dopamine and Norepinephrine in the Hypothalamus and Hippocampus of Immature Spontaneously Hypertensive Rats

LI Yaping; LI Wei; LI Rui; YANG Changquan; WEI Xiaowei; WANG Wei; ZHONG Chengliang; JIN Li; WU Haijiao; TANG Wen

doi:10.13288/j.11-2166/r.2018.24.015

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Effects of Yizhi Ningshen Granules（益智宁神颗粒） on Dopamine and Norepinephrine in the Hypothalamus and Hippocampus of Immature Spontaneously Hypertensive Rats

更新时间：2021-11-10

- Effects of Yizhi Ningshen Granules（益智宁神颗粒） on Dopamine and Norepinephrine in the Hypothalamus and Hippocampus of Immature Spontaneously Hypertensive Rats
- Journal of Traditional Chinese Medicine Vol. 59, Issue 24, Pages: 2138-2141(2018)
- 作者机构：
  
  1. 天津中医药大学第一附属医院
  2. 天津中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2018.24.015
  CLC： R285.5
- Published：2018
- 稿件说明：
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[1]李亚平,李巍,李瑞,杨常泉,魏小维,王伟,钟成梁,晋黎,吴海娇,唐温.益智宁神颗粒对自发性高血压幼鼠下丘脑、海马中多巴胺及去甲肾上腺素的影响[J].中医杂志,2018,59(24):2138-2141.

LI Yaping, LI Wei, LI Rui, et al. Effects of Yizhi Ningshen Granules（益智宁神颗粒） on Dopamine and Norepinephrine in the Hypothalamus and Hippocampus of Immature Spontaneously Hypertensive Rats[J]. Journal of Traditional Chinese Medicine2018, 59(24): 2138-2141.
[1]李亚平,李巍,李瑞,杨常泉,魏小维,王伟,钟成梁,晋黎,吴海娇,唐温.益智宁神颗粒对自发性高血压幼鼠下丘脑、海马中多巴胺及去甲肾上腺素的影响[J].中医杂志,2018,59(24):2138-2141. DOI： 10.13288/j.11-2166/r.2018.24.015.

LI Yaping, LI Wei, LI Rui, et al. Effects of Yizhi Ningshen Granules（益智宁神颗粒） on Dopamine and Norepinephrine in the Hypothalamus and Hippocampus of Immature Spontaneously Hypertensive Rats[J]. Journal of Traditional Chinese Medicine2018, 59(24): 2138-2141. DOI： 10.13288/j.11-2166/r.2018.24.015.

摘要

目的探讨益智宁神颗粒治疗注意缺陷多动障碍（ADHD）的可能作用机制。方法 24只自发性高血压（SHR）幼鼠随机分为模型组、中药组、托莫西汀组、哌甲酯组

每组6只。6只京都大鼠（WKY）设为正常组。中药组给予益智宁神颗粒1. 1 g/（kg·d）灌胃

托莫西汀组给予托莫西汀胶囊3 mg/（kg·d）灌胃

哌甲酯组给予哌甲酯片5 mg/（kg·d）灌胃

模型组和正常组给予与中药组等体积生理盐水灌胃。灌胃4周后检测各组大鼠海马及下丘脑内多巴胺（DA）及去甲肾上腺素（NE）含量。结果与正常组比较

模型组下丘脑DA含量升高

海马DA含量降低（P <0. 05）

下丘脑、海马NE均无明显变化（P> 0. 05）;与模型组比较

各给药组下丘脑DA含量差异均无统计学意义（P> 0. 05）

托莫西汀组、哌甲酯组海马DA含量升高（P <0. 05）

中药组海马DA差异无统计学意义（P> 0. 05）;与中药组比较

托莫西汀组下丘脑DA含量升高（P <0. 05）;托莫西汀组、哌甲酯组海马DA含量升高

且哌甲酯组海马DA含量高于托莫西汀组（P <0. 05）。结论益智宁神颗粒治疗ADHD可能通过调节DA含量起作用

且不同脑区调节作用不同。

Abstract

Objective To explore the possible action mechanism of Yizhi Ningshen Granules（益智宁神颗粒） in the treatment of attention deficit hyperactivity disorder（ADHD）. Methods A total of 24 immature spontaneously hypertensive rats（SHR） were randomly divided into a model group

a Chinese medicine group

a tomoxetine group

and a methylphenidate group

with 6 rats in each group

and 6 WKY were selected as the normal group. The Chinese medicine group was given Yizhi Ningshen Granules 1. 1 g/（kg·d） by intragastric perfusion

the tomoxetine group was given tomoxetine capsules 3 mg/（kg·d）

and the methylphenidate group was given methylphenidate tablets 5 mg/（kg·d） for gavage

the model group and the normal group were given normal saline with the same volume of the Chinese medicine group. After 4 weeks of gavage

the contents of dopamine（DA） and norepinephrine（NE） in hippocampus and hypothalamus were detected. Results Compared with the normal group

the DA content in the hypothalamus of the model group increased

and the DA content in the hippocampus decreased（P < 0. 05）

while NE in the hypothalamic and hippocampal did not change significantly（P > 0. 05）. Compared with the model group

there was no significant difference in the content of DA in the hypothalamus in all other groups（P > 0. 05）. The contents of DA in the hippocampus of the tomoxetine group and the methylphenidate group were increased（P < 0. 05）. There was no statistically significant difference in the contents of DA in hippocampus of Chinese medicine group（P >0. 05）. Compared with the Chinese medicine group

the DA content in the hypothalamus of the tomoxetine group was increased（P < 0. 05）. The content of DA in the hippocampus of the tomoxetine group and the methylphenidate group was increased

and the content of DA in the hippocampus of the methylphenidate group was higher than that of tomoxetine group（P < 0. 05）. Conclusion Yizhi Ningshen Granules in the treatment of ADHD may have functions through regulating DA content

and the regulatory effects are different in different brain regions.

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