Objective To analyze the core herb and the prescription regularity of traditional Chinese medicine（TCM） treatment of Parkinson disease. Methods A comprehensive literature search was performed in China National Knowledge Infrastructure（CNKI）

Wanfang Database

VIP database

and China Biology Medicine（CBM） to identify all the studies on TCM prescription in the treatment of Parkinson disease

the literature was from database establishment to March 31

2018. BICOMB 2 was used to extract all the information of drug name and to generate a cooccurrence matrix. Gcluto was used to draw clustering matrix maps and mountain diagrams. NetDraw was used to draw network maps

and the frequency of drugs and drug groups for the treatment of Parkinson’ s disease were analyzed.Results A total of 762 papers were included

which covered 1389 TCM prescriptions

with 325 kinds of herbs in 22 categories. Baishao（Radix Paeoniae Alba） appeared most frequently（759）

followed by Tianma（Rhizoma Gastrodiae

546） and Shudihuang（Rehmannia Glutinosa

545）

Danggui（Radix Angelicae Sinensis

538）

Gouteng（Uncaria rhynchophylla

513）. According to function classification

tonic herbals（64 ingredients） was in dominant position

followed by heat-clearing herbs（41 ingredients）

rheumatism herbals（32 ingredients）

and blood-activating herbs and expectorant herbals（26 ingredients）

which makes 51. 74% of the total number of ingredients. The herb pairs with highest frequency was Shudihuang（Rehmannia Glutinosa） with Baishao（Radix Paeoniae Alba

395）

followed by Tianma（Rhizoma Gastrodiae） and Guoteng（Uncaria rhynchophylla

357）

Tianma（Rhizoma Gastrodiae）with Baishao（Radix Paeoniae Alba

353）

Danggui（Radix Angelicae Sinensis） with Baishao（Radix Paeoniae Alba

352）

and Guoteng（Uncaria rhynchophylla） with Baishao（Radix Paeoniae Alba

325）. Conclusion The methods of TCM in treating Parkinson disease mainly include dispersing stagnated liver qi to dredge collateral

nourishing kidney to tonify marrow

dispelling wind damp and regulating meridian and collateral

which mainly use Baishao（Radix Paeoniae Alba）

Tianma（Rhizoma Gastrodiae）

Shudihuang（Rehmannia Glutinosa）

Danggui（Radix Angelicae Sinensis） and Guotneg（Uncaria rhynchophylla） as core herbs.