History of Application of Arsenious Acid Injection in the Treatment of Acute Promyelocytic Leukemia

BAI Yunlong; SHAN Hongli; ZHOU Jin

doi:10.13288/j.11-2166/r.2019.01.008

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History of Application of Arsenious Acid Injection in the Treatment of Acute Promyelocytic Leukemia

更新时间：2021-11-10

- History of Application of Arsenious Acid Injection in the Treatment of Acute Promyelocytic Leukemia
- Journal of Traditional Chinese Medicine Vol. 60, Issue 1, Pages: 28-30(2019)
- 作者机构：
  
  1. 哈尔滨医科大学药学院
  2. 哈尔滨医科大学附属第一临床医学院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2019.01.008
  CLC： R733.71
- Published：2019
- 稿件说明：
移动端阅览
[1]白云龙,单宏丽,周晋.亚砷酸注射液应用于急性早幼粒细胞白血病治疗的历程[J].中医杂志,2019,60(01):28-30.

BAI Yunlong, SHAN Hongli, ZHOU Jin. History of Application of Arsenious Acid Injection in the Treatment of Acute Promyelocytic Leukemia[J]. Journal of Traditional Chinese Medicine2019, 60(1): 28-30.
[1]白云龙,单宏丽,周晋.亚砷酸注射液应用于急性早幼粒细胞白血病治疗的历程[J].中医杂志,2019,60(01):28-30. DOI： 10.13288/j.11-2166/r.2019.01.008.

BAI Yunlong, SHAN Hongli, ZHOU Jin. History of Application of Arsenious Acid Injection in the Treatment of Acute Promyelocytic Leukemia[J]. Journal of Traditional Chinese Medicine2019, 60(1): 28-30. DOI： 10.13288/j.11-2166/r.2019.01.008.

摘要

20世纪70年代开始

哈尔滨医科大学附属第一医院张亭栋团队经过充分研究

将亚砷酸（三氧化二砷）为主要成分的癌灵注射液应用于白血病患者的治疗

发现其尤其适用于急性早幼粒细胞白血病。鉴于其存在的副作用

又于1995年开始

联合上海瑞金医院陈竺教授开展了三氧化二砷毒性反应发生机制研究。根据研究结果创立了亚砷酸持续缓慢静脉输注法

基本解决了砷剂治疗急性早幼粒细胞性白血病中的高白细胞血症和长QT间期综合征等临床医学中的疑难问题。该系列研究极大地提高了急性早幼粒细胞白血病的临床疗效与安全性。

Abstract

Since the 1970 s

the team of ZHANG Tingdong of the First Affiliated Hospital of Harbin Medical University has fully studied the application of Ailing Injection（癌灵注射液） with the main component of arsenic trioxide in the treatment of leukemia patients

and found that it is especially suitable for acute promyelocytic leukemia. In view of its side effects

they conducted research on the mechanism of arsenic trioxide toxicity together with Professor CHEN Zhu from Shanghai Ruijin Hospital in 1995. According to the research results

the continuous slow intravenous infusion of arsenic acid was established

which basically solved the difficult problems in the clinical medicine such as hyperleukocytosis and long QT syndrome in arsenic treatment of acute promyelocytic leukemia. This series of studies have greatly improved the clinical efficacy and safety of acute promyelocytic leukemia.

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