Objective To investigate the characteristics of plasma metabolomics in chronic atrophic gastritis（CAG） patients with spleen-stomach dampness-heat syndrome and spleen-stomach cold and deficiency syndrome.Methods A total of 45 cases of CAG were selected

with 28 cases of spleen-stomach dampness-heat syndrome and17 cases of spleen-stomach deficiency-cold syndrome

and 40 cases of healthy volunteers were selected as the normal group. There was 5 m L of venous blood that was collected from each group

and the contents of plasma metabolites were determined quantitatively by1 H-NMR

and the principal component analysis（PCA）

partial least squares discriminant analysis（PLS-DA） and orthogonal partial least squares discriminant analysis（OPLS-DA） were used for multivariate statistical analysis. Results A total of 11 potential biomarkers were screened

among them

glucose

alanine

valine levels were higher in CAG patients than in healthy individuals

while glutamine

glycine

lactic acid and glycine betaine were significantly lower than those in healthy individuals. Valine and lactulose in patients with spleen-stomach dampness-heat syndrome were higher than those with spleen-stomach deficiency-cold syndrome

while isobutyric acid

formic acid and carnosine were lower than those with spleen-stomach deficiency-cold syndrome.Conclusion Chronic atrophic gastritis patients with spleen and stomach deficiency syndrome and spleen-stomach damp-heat syndrome have obvious disorders of glucose metabolism and amino acid catabolism

and there are differences in glucose metabolism

lipid metabolism

amino acid metabolism and nucleic acid metabolism between the two syndromes.