Effects of Chinese Medicine Mimenghua （Flos Buddlejae） Iontophoresis on Interleukin-6,Intercellular Adhesion Molecule-1 in Tear of Dry Eye Patients

ZENG Zhicheng; PENG Jun; YAO Xiaolei; PENG Qinghua

doi:10.13288/j.11-2166/r.2019.03.010

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Effects of Chinese Medicine Mimenghua （Flos Buddlejae） Iontophoresis on Interleukin-6,Intercellular Adhesion Molecule-1 in Tear of Dry Eye Patients

更新时间：2021-11-10

- Effects of Chinese Medicine Mimenghua （Flos Buddlejae） Iontophoresis on Interleukin-6,Intercellular Adhesion Molecule-1 in Tear of Dry Eye Patients
- Journal of Traditional Chinese Medicine Vol. 60, Issue 3, Pages: 219-223(2019)
- 作者机构：
  
  1. 湖南中医药大学第一附属医院
  2. 湖南省桂阳县第一人民医院
  3. 湖南中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2019.03.010
  CLC： R276.7
- Published：2019
- 稿件说明：
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[1]曾志成,彭俊,姚小磊,彭清华.中药密蒙花离子导入对干眼患者泪液白细胞介素6、细胞间黏附分子1表达的影响[J].中医杂志,2019,60(03):219-223.

ZENG Zhicheng, PENG Jun, YAO Xiaolei, et al. Effects of Chinese Medicine Mimenghua （Flos Buddlejae） Iontophoresis on Interleukin-6,Intercellular Adhesion Molecule-1 in Tear of Dry Eye Patients[J]. Journal of Traditional Chinese Medicine2019, 60(3): 219-223.
[1]曾志成,彭俊,姚小磊,彭清华.中药密蒙花离子导入对干眼患者泪液白细胞介素6、细胞间黏附分子1表达的影响[J].中医杂志,2019,60(03):219-223. DOI： 10.13288/j.11-2166/r.2019.03.010.

ZENG Zhicheng, PENG Jun, YAO Xiaolei, et al. Effects of Chinese Medicine Mimenghua （Flos Buddlejae） Iontophoresis on Interleukin-6,Intercellular Adhesion Molecule-1 in Tear of Dry Eye Patients[J]. Journal of Traditional Chinese Medicine2019, 60(3): 219-223. DOI： 10.13288/j.11-2166/r.2019.03.010.

摘要

目的观察中药密蒙花离子导入治疗干眼的疗效及可能作用机制。方法将60例（120眼）干眼患者随机分为观察组（30例60眼）和对照组（30例60眼）。观察组予以中药密蒙花离子导入和玻璃酸钠滴眼液滴眼

对照组仅予以玻璃酸钠滴眼液滴眼

共治疗4周。于治疗前及治疗2、4周后比较两组患者干眼症状问卷评分、基础泪液分泌（Schirmer-Ⅰ）、泪膜破裂时间（BUT）、角膜染色评分和泪液白细胞介素6（IL-6）、细胞间黏附分子1 （ICAM-1）表达

治疗4周后评价临床疗效

随访3个月观察干眼复发情况。结果观察组临床疗效总有效率为93. 33%

对照组为80. 00%

观察组临床疗效优于对照组（P <0. 01）。治疗2、4周后

两组患者干眼症状问卷评分、Schirmer-Ⅰ、BUT、角膜染色评分和泪液IL-6、ICAM-1表达与本组治疗前比较均明显改善

且观察组均优于对照组（P <0. 05或P <0. 01）。随访3个月

观察组复发率为14. 81%

低于对照组的39. 2%（P <0. 05）。结论中药密蒙花通过离子导入眼表组织

可消除或缓解干眼患者症状

降低复发率

抑制IL-6和ICAM-1炎症因子表达可能是其机制之一。

Abstract

Objective To observe the effects of Chinese medicine Mimenghua（ Flos Buddlejae） Iontophoresis on interleukin-6（ IL-6）

intercellular adhesion molecule-1（ ICAM-1） in tear of dry eye patients and its possible mechanism. Methods A total of 60 patients（ 120 eyes） with dry eye were randomly divided into observation group（ 30 patients

60 eyes） and control group（ 30 patients

60 eyes）. The observation group was treated by Chinese medicine Flos Buddlejae iontophoresis and sodium hyaluronate eye drops

and the control group was only treated by sodium hyaluronate eye drops

for totally 4 weeks. The dry eye symptoms questionnaire scores

Schirmer-Ⅰtest

break-up time（ BUT）

cornea staining scores and the expression of IL-6

ICAM-1 in tear were compared before treatment and 2 and4 weeks after treatment. The curative effects were evaluated after 4 weeks’ treatment. The recurrence of dry eye was observed after 3 months of follow-up. Results The total effective rate was 93. 33% and 80. 00% in observation group in the control group. The clinical efficacy in the observation group was more significant（ P < 0. 01）. After 2 weeks and 4 weeks treatment

dry eye symptoms questionnaire scores

Schirmer-Ⅰtest

BUT test

cornea staining scores and tear IL-6

ICAM-1 expression of two groups were significantly improved

and the observation group was better than the control group（ P < 0. 05 or P < 0. 01）. After 3 months’ follow-up

the recurrence rate of the observation group was 14. 81%

which was lower than 39. 2% in the control group（ P < 0. 05）. Conclusion Chinese medicine Flos Buddlejae covered ocular surface by iontophoresis can eliminate or alleviate symptoms of dry eye patient

and reduce recurrence rate

the possible mechanisim might be inhibiting the expression of inflammatory cytokines IL-6 and ICAM-1.

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Related Institution

School of Chinese Medicine，Anhui University of Chinese Medicine

The First Affiliated Hospital of Anhui University of Chinese Medicine

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Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine

Hunan University of Chinese Medicine

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