Objective To explore the effects of tonifying kidney and benefiting marrow method on non-motor symptoms of Parkinson’ s disease with kidney deficiency and marrow reduction. Methods A total of 60 patients with Parkinson’s disease with kidney deficiency and marrow reduction were randomly divided into a treatment group and a control group. Both groups were treated based on the western medicine of anti-Parkinson’ s disease

and the treatment group was added with the recipe of tonifying kidney and benefiting marrow method for 3 months. The Parkinson disease sleep scale（ PDSS）

fatigue scale

Epworth somnolence scale

and constipation scale were scored before treatment

1 and 3 months after treatment. The Montreal cognitive assessment scale（ MoCA） was used to explore the clinical effects. Results After 3 months’ treatment

the total effective rate was 90. 00% in the treatment group

and 66. 67% in the control group

the treatment group significantly higher than the control group（ P < 0. 05）. After 3 months’ treatment

scores of the PDSS

fatigue scale

Epworth somnolence scale

and constipation scale of the treatment group were lower than before treatment

and lower than the control group at the same time（ P < 0. 05）. There was no difference in the MoCA score of the 2 groups before and after treatment（ P > 0. 05）. Conclusion Tonifying kidney and benefiting marrow method is effective in improving the non-motor symptoms of Parkinson’ s disease with kidney deficiency and marrow reduction

such as fatigue

daytime sleepiness

sleep disorders and constipation.