Effects of Huqi Formula（槲芪方） on Quality of Life of Primary Liver Cancer of Vital Qi Deficiency and Toxin-Blood Stasis Coagulation Syndrom: A Retrospective Cohort Study

ZHANG Liang; YANG Jinxiang; LI Xiuhui; ZHANG Xiangying; Wang Huijuan

doi:10.13288/j.11-2166/r.2019.04.010

您当前的位置：

首页 >

文章列表页 >

Effects of Huqi Formula（槲芪方） on Quality of Life of Primary Liver Cancer of Vital Qi Deficiency and Toxin-Blood Stasis Coagulation Syndrom: A Retrospective Cohort Study

更新时间：2021-11-10

- Effects of Huqi Formula（槲芪方） on Quality of Life of Primary Liver Cancer of Vital Qi Deficiency and Toxin-Blood Stasis Coagulation Syndrom: A Retrospective Cohort Study
- Journal of Traditional Chinese Medicine Vol. 60, Issue 4, Pages: 306-310(2019)
- 作者机构：
  
  1. 北京中医药大学
  2. 北京中医药大学第三附属医院
  3. 首都医科大学附属北京佑安医院
  4. 首都医科大学附属北京佑安医院北京市肝病研究所
  5. 山西医科大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2019.04.010
  CLC： R735.7
- Published：2019
- 稿件说明：
移动端阅览
[1]张亮,杨晋翔,李秀惠,张向颖,王慧娟.槲芪方加减对原发性肝癌正气不足、毒瘀内结证患者肝动脉化疗栓塞术后生活质量影响的回顾性队列研究[J].中医杂志,2019,60(04):306-310.

ZHANG Liang, YANG Jinxiang, LI Xiuhui, et al. Effects of Huqi Formula（槲芪方） on Quality of Life of Primary Liver Cancer of Vital Qi Deficiency and Toxin-Blood Stasis Coagulation Syndrom: A Retrospective Cohort Study[J]. Journal of Traditional Chinese Medicine2019, 60(4): 306-310.
[1]张亮,杨晋翔,李秀惠,张向颖,王慧娟.槲芪方加减对原发性肝癌正气不足、毒瘀内结证患者肝动脉化疗栓塞术后生活质量影响的回顾性队列研究[J].中医杂志,2019,60(04):306-310. DOI： 10.13288/j.11-2166/r.2019.04.010.

ZHANG Liang, YANG Jinxiang, LI Xiuhui, et al. Effects of Huqi Formula（槲芪方） on Quality of Life of Primary Liver Cancer of Vital Qi Deficiency and Toxin-Blood Stasis Coagulation Syndrom: A Retrospective Cohort Study[J]. Journal of Traditional Chinese Medicine2019, 60(4): 306-310. DOI： 10.13288/j.11-2166/r.2019.04.010.

摘要

目的评价槲芪方加减对原发性肝癌正气不足、毒瘀内结证患者肝动脉化疗栓塞术（TACE）后生活质量的影响。方法采用回顾性队列研究方法

收集2013年1月至2016年11月在首都医科大学附属北京佑安医院明确诊断为原发性肝癌并经TACE治疗的病例

按照是否服用中药斛芪方加减治疗将患者分为治疗组88例和对照组89例

对照组术后给予西医常规治疗

治疗组在西医常规治疗基础上口服斛芪方加减

每日1剂

两组共治疗24周。比较两组治疗前后中医证候积分、生活质量评分（QOL）、肝功能[丙氨酸氨基转移酶（ALT）、门冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）、谷氨酰转肽酶（GGT）、总胆红素（TBiL）、直接胆红素（DBiL）、白蛋白（ALB）]及甲胎蛋白（AFP）水平

并判定中医证候疗效。结果两组治疗后中医证候积分均较治疗前降低

且治疗组较对照组降低更明显（P <0. 01）。治疗组中医证候疗效总有效率为60. 23%

对照组为7. 86%

治疗组疗效优于对照组（P <0. 01）。治疗组治疗后QOL评分较治疗前升高

并明显高于对照组治疗后（P <0. 01）。两组患者治疗后ALT、AST、ALP、DBi L、TBi L较本组治疗前比较差异无统计学意义（P>0. 05）

治疗后治疗组GGT水平低于对照组

ALB水平高于对照组（P <0. 05）。治疗组54例患者中AFP下降13例（24. 07%）

对照组83例中下降29例（34. 94%）

两组比较差异无统计学意义（P> 0. 05）。结论槲芪方加减能够明显改善原发性肝癌正气不足、毒瘀内结证患者TACE后的临床症状

提高生活质量。

Abstract

Objective To evaluate the clinical effects of Huqi Formula（槲芪方） on quality of life（ QOL） of primary liver cancer patients with vital qi deficiency and toxin-blood stasis coagulation syndrom after transhepatic arterial chemotherapy and embolization（ TACE）. Methods A retrospective cohort study method was conducted

and the patients who were selected from Beijing You’an Hospital

Capital Medical University from January 2013 to November 2016 with primary liver cancer treated by TACE were divided into treatment group of 88 cases and control group of89 cases according to taking Chinese medicine or not. Both groups were observed for 24 weeks. The control group was given conventional western therapy

and the treatment group was given oral Huqi Formula on the basis of the control group. The traditional Chinese medicine（ TCM） symptoms scores

QOL

liver functions such as alanine aminotransferase（ ALT）

aspartate aminotransferase（ AST）

alkaline phosphatase（ ALP）

glutamyltranspeptidase（ GGT）

total bilirubin（ TBiL）

direct bilirubin（ DBiL）

albumin（ ALB）

and alpha fetoprotein（ AFP） level before and after therapy were compared to determine the efficacy of TCM syndromes. Results After treatment

TCM syndrome scores in both groups were lower than those before treatment

and the treatment group was obvious than the control group（ P < 0. 01）. The total effective rate of TCM syndrome in the treatment group was 60. 23%

and that in the control group was 7. 86%. The treatment group was superior to the control group（ P < 0. 01）. QOL score of the treatment group increased after treatment compared with that before treatment

and was significantly higher than that of the control group（ P < 0. 01）. After treatment

ALT

AST

ALP

DBiL and TBiL in both groups showed no statistical significance compared with that before treatment（ P > 0. 05）. After treatment

GGT level in the treatment group was lower than that in the control group

and ALB level was higher than that in the control group（ P < 0. 05）. AFP level in 13 patients of 54（ 24. 07%） in the treatment group and 29 of 83（ 34. 94%） in the control group was decreased.There was no significant difference between the two groups（ P > 0. 05）. Conclusion Huqi Formula can obviously improve the clinical symptoms and QOL of primary liver cancer patients with vital qi deficiency and toxin-blood stasis coagulation after TACE.

关键词

Keywords

references

查看原文

Views

314

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

A Clinical Observation on Supplemented Yiguan Brew Combined with Transcatheter Hepatic Arterial Chemo-Embolization for 42 Cases of Primary Liver Cancer

Combined with Western Medicine Therapy in the Treatment of 80 Cases of Hepatitis B Related Primary Liver Cancer with the Syndrome of Deficiency of Qi and Yin, and Acummulation of Toxin and Stasis

Effect of Heat-sensitive Moxibustion on Quality of Life and Immune Function in Non-Small Cell Lung Cancer Patients with Qi Deficiency and Phlegm Stasis Syndrome Undergoing Chemotherapy：A Randomized Controlled Trial

Effect of Optimized New Shengmai Powder （优化新生脉散方） on Exercise Tolerance in Patients with Chronic Heart Failure of Qi Deficiency，Blood Stasis and Fluid Retention Syndrome：A Randomized，Double-Blind，Placebo-Controlled Trial

Effectiveness Evaluation of Exhalation-Inhalation Exercise on Early Pulmonary Rehabilitation for Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Related Author

LU Yiqiong

LI Huabo

LIU Huimin

WANG Xinhui

LIU Xiaoli

SHI Ke

LI Yuxin

JIANG Yuyong

Related Institution

Minda Hospital Affiliated to Hubei University for Nationalities

Beijing Ditan Hospital,Capital Medical University

Guangdong Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Guangzhou University of Chinese Medicine

Jinan Vocational College of Nurisng，Shandong Pronvince

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/ National Clinical Research Center for Chinese Medicine

Address：No.16, Nanxiao street, Dongzhimen, Dongcheng District, Beijing Postal code：100700
Tel：010-64035632 Email：jtcmcn@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010102007558号
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰