Correlation Between Chinese Medicine Channel Ushering Theory,Signal Pathway and Bone Marrow Mesenchymal Stem Cells

LI Yingfu; XIE Xingwen; LI Ning; SONG Min; ZHOU Wenjie; JIANG Guopeng

doi:10.13288/j.11-2166/r.2019.06.007

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Correlation Between Chinese Medicine Channel Ushering Theory,Signal Pathway and Bone Marrow Mesenchymal Stem Cells

更新时间：2021-11-10

- Correlation Between Chinese Medicine Channel Ushering Theory,Signal Pathway and Bone Marrow Mesenchymal Stem Cells
- Journal of Traditional Chinese Medicine Vol. 60, Issue 6, Pages: 477-481(2019)
- 作者机构：
  
  1. 甘肃省中医院
  2. 甘肃中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2019.06.007
  CLC： R22
- Published：2019
- 稿件说明：
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[1]李应福,谢兴文,李宁,宋敏,周文杰,蒋国鹏.引经理论与骨髓间充质干细胞、信号通路的相关性[J].中医杂志,2019,60(06):477-481.

LI Yingfu, XIE Xingwen, LI Ning, et al. Correlation Between Chinese Medicine Channel Ushering Theory,Signal Pathway and Bone Marrow Mesenchymal Stem Cells[J]. Journal of Traditional Chinese Medicine2019, 60(6): 477-481.
[1]李应福,谢兴文,李宁,宋敏,周文杰,蒋国鹏.引经理论与骨髓间充质干细胞、信号通路的相关性[J].中医杂志,2019,60(06):477-481. DOI： 10.13288/j.11-2166/r.2019.06.007.

LI Yingfu, XIE Xingwen, LI Ning, et al. Correlation Between Chinese Medicine Channel Ushering Theory,Signal Pathway and Bone Marrow Mesenchymal Stem Cells[J]. Journal of Traditional Chinese Medicine2019, 60(6): 477-481. DOI： 10.13288/j.11-2166/r.2019.06.007.

摘要

中医引经理论是中医学理论的重要内容

引经药可以引导与之同用的其他药物达于病所而提高疗效。骨髓间充质干细胞（BMSCs）存在于骨髓中

具有高度自我更新能力和自我复制能力

并可多向分化。通过分析骨髓间充质干细胞与磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B （Akt）、MCP-1/CCR2、SDF-1/CX-CR4、MAPK/ERK1/2信号通路间的关联性与转导性

探讨引经药促进骨髓间充质干细胞迁移的机制。

Abstract

Chinese medicine channel ushering theory is an important content in the theory of traditional Chinese medicine. The channel ushering drugs can guide other drugs to reach the disease location and improve the curative effect. Bone marrow mesenchymal stem cells（BMSCs） are present in the bone marrow and have a high degree of selfrenewal and self-replication ability

and can be multi-directionally differentiated. Through analyzing the relationship and transduction between bone marrow mesenchymal stem cells and PI3 K/AKT

MCP-1/CCR2

SDF-1/CXCR4

MAPK/ERK1/2

PKC signaling pathways

this paper discussed the action of promoting the migration of bone marrow mesenchymal stem cells by channel ushering drug.

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