Meta-analysis of Randomized Controlled Clinical Study on Modified Linggui Zhugan Decoction（苓桂术甘汤） Combined with Conventional Western Medicine in the Treatment of Chronic Heart Failure

ZHANG Hongyuan; LIU Yue; WANG Yang; LIU Guanghui; ZHANG Zhe; YANG Guanlin

doi:10.13288/j.11-2166/r.2019.06.010

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Meta-analysis of Randomized Controlled Clinical Study on Modified Linggui Zhugan Decoction（苓桂术甘汤） Combined with Conventional Western Medicine in the Treatment of Chronic Heart Failure

更新时间：2021-11-10

- Meta-analysis of Randomized Controlled Clinical Study on Modified Linggui Zhugan Decoction（苓桂术甘汤） Combined with Conventional Western Medicine in the Treatment of Chronic Heart Failure
- Journal of Traditional Chinese Medicine Vol. 60, Issue 6, Pages: 492-496(2019)
- 作者机构：
  
  1. 辽宁中医药大学
  2. 辽宁中医药大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2019.06.010
  CLC： R541.6
- Published：2019
- 稿件说明：
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[1]张洪源,刘悦,王洋,刘光辉,张哲,杨关林.苓桂术甘汤加减联合常规西药治疗慢性心力衰竭随机对照临床研究Meta分析[J].中医杂志,2019,60(06):492-496.

ZHANG Hongyuan, LIU Yue, WANG Yang, et al. Meta-analysis of Randomized Controlled Clinical Study on Modified Linggui Zhugan Decoction（苓桂术甘汤） Combined with Conventional Western Medicine in the Treatment of Chronic Heart Failure[J]. Journal of Traditional Chinese Medicine2019, 60(6): 492-496.
[1]张洪源,刘悦,王洋,刘光辉,张哲,杨关林.苓桂术甘汤加减联合常规西药治疗慢性心力衰竭随机对照临床研究Meta分析[J].中医杂志,2019,60(06):492-496. DOI： 10.13288/j.11-2166/r.2019.06.010.

ZHANG Hongyuan, LIU Yue, WANG Yang, et al. Meta-analysis of Randomized Controlled Clinical Study on Modified Linggui Zhugan Decoction（苓桂术甘汤） Combined with Conventional Western Medicine in the Treatment of Chronic Heart Failure[J]. Journal of Traditional Chinese Medicine2019, 60(6): 492-496. DOI： 10.13288/j.11-2166/r.2019.06.010.

摘要

目的对苓桂术甘汤加减联合常规西药治疗慢性心力衰竭的临床疗效进行系统评价。方法计算机检索中国知网（CNKI）、维普中文科技期刊数据库（VIP）、万方数据库（WANFANG DATE）、中国生物医学文献数据库（CBM）、PubMed数据库和Cochrane图书馆

所有数据库检索时限均为建库至2018年3月31日

以苓桂术甘汤加减联合常规西药治疗慢性心力衰竭的随机对照试验为研究对象

对照组采用西药常规治疗

治疗组在对照组基础上加用苓桂术甘汤加减

并对纳入文献进行质量评价和资料提取

采用RevMan 5. 3软件进行数据分析。结果共纳入8项研究

834例患者。Meta分析结果显示:治疗组临床有效率优于对照组[RR=1. 18

95%CI （1. 11

1. 25）

P <0. 00001];治疗组提高患者左室射血分数优于对照组[MD=8. 38

95%CI （2. 65

14. 11）

P=0. 004];治疗组减少患者左室舒张末内径优于对照组[MD=-6. 82

95%CI （-12. 52

-1. 11）

P=0. 02];治疗组降低患者血清N末端脑钠肽（NT-proBNP）血清水平优于对照组[SMD=-3. 53

95%CI （-5. 31

-1. 74）

P <0. 001];治疗组增加患者6分钟步行距离效果优于对照组[MD=56. 87

95%CI （25. 18

88. 55）

P=0. 0004]。证据等级显示

总有效率、血清NT-proBNP水平和患者6分钟步行距离为极低级

左室射血分数和左室舒张末内径为低级

推荐强度均为弱推荐。结论苓桂术甘汤加减联合常规西药治疗慢性心力衰竭可明显提高患者临床有效率和左室射血分数

减小左室舒张末期内径

降低血清NT-proBNP水平

增加患者的6分钟步行试验距离。

Abstract

Objective To systematically evaluate the clinical effects of Modified Linggui Zhugan Decoction（苓桂术甘汤） in the treatment of chronic heart failure（CHF）. Methods The Chinese National Knowledge Infrastructure（CNKI）

VIP Database

WANFANG Database

China Biology Medicine（CBM）

PubMed and Cochrane library were searched for randomized controlled trials of Modified Linggui Zhugan Decoction in the treatment of CHF by computers

with retrieval time from database establishment to March 31

2018. The control group was treated with routine western medicine

while the treatment group was additionally treated with modified Linggui Zhugan Decoction. The quality evaluation and data extraction were conducted to included literature. The RevMan 5. 3 software was used for data analysis. Results A total of 8 studies were included with 834 cases. Meta-analysis showed that the clinical effective rate of the treatment group was better than the control [RR = 1. 18

95% CI（1. 11

1. 25）

P < 0. 00001].The treatment group improved left ventricular ejection fraction（LVEF）

which was better than the control group[MD = 8. 38

95% CI（2. 65

14. 11）

P = 0. 004]. The treatment group reduced the left ventricular end-diastolic dimension（LVEDD）

which was better than that of the control group [MD =-6. 82

95% CI（-12. 52

-1. 11）

P = 0. 02]. The treatment group reduced the serum NT-proBNP level

which was better than that of the control group[SMD =-3. 53

95% CI（-5. 31

-1. 74）

P < 0. 0001]. The effect of the treatment group on increasing CHF patients’ 6 minutes walking distance was better than that of the control group [MD = 56. 87

95% CI（25. 18

88. 55）

P = 0. 0004]. The grade of evidence showed that the total effective rate

the serum NT-proBNP level and the 6 minute walk distance were extremely low

and LVEF and LVEDD were low. The recommended intensity was weak recommendation. Conclusion Modified Linggui Zhugan Decoction combined with conventional western medicine in the treatment of chronic heart failure can significantly improve the clinical effective rate and LVEF

reduced LVEDD and serum NT-proBNP level

increase CHF patients’ 6 minutes walking distance.

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