Professor CHAI Kequn holds that deficiency of liver yin

deficiency of spleen qi

exhaustion of kidney essence and inclusion in dampness heat are the characteristics of liver cancer pathogenesis. The four principles and four methods of traditional Chinese medicine（ TCM） in treating liver cancer based on syndrome differentiation were developed according to the pathogenesis

which are principles of "strengthening and consolidating body resistance

proper eliminating pathogenic factors

regulating mind during whole process

and treatment along syndrome "and methods of "strengthening spleen qi and reinforcing kidney essence

dissolving phlegm and detoxifying

dispersing stagnated liver qi for relieving stagnation

and warming yang and dredging collaterals". By expounding the connotation of four principles and four methods of TCM in treating liver cancer based on syndrome differentiation and its application in liver cancer

this paper summarized the experience of CHAI Kequn in the treatment of liver cancer by using four principles and four methods. The four methods of TCM differentiation were flexibly used for different stages of liver cancer

in line with the nature of liver cancer

and it has a good guiding significance for the clinic.