Objective To explore the short-term survival rate of patients with hepatitis B virus（ HBV）-related acute-on-chronic liver failure（ ACLF） based on the syndrome differentiation of "Yang Jaundice-Yin-Yang JaundicesYin Jaundice"and combined with western medicine

and its affecting factors. Methods Using the multicenter and randomized controlled clinical trials

a total of 413 cases were collected from 12 clinical trials centers from May 2012 to July 2016

and they were randomly divided into 237 cases of the treatment group and 176 cases of the control group. The control group was treated with comprehensive western medicine

and the treatment group was treated with syndrome differentiation of "Yang Jaundice-Yin-Yang Jaundices-Yin Jaundice"based on the control group. After 8 weeks of treatment

the survival condition of the 2 groups were compared. Cox risk proportional regression model was used to screen independent risk factors affecting patient’s short-term survival rate. Results The average 8 weeks’ survival time of the treatment group was longer than that of the control group（ P = 0. 023）. The Cox regression analysis showed that age over 56 years old

advanced stage and hepatic encephalopathy were independent risk factors that increase short-term mortality. The relative risk [Exp（ β） ] of above three independent risk factors were 4. 045

4. 279 and 4. 313 respectively. The integrative Chinese and western medicine treatment [Exp（ β） : 0. 493]and prothrombin activity（ PTA） [Exp（ β） : 0. 146) ]were protective factors that decrease the short-term mortality. Conclusion The integrative Chinese and western medicine based on the syndrome differentiation of"Yang Jaundice-YinYang Jaundices-Yin Jaundice"can increase the short-term survival rate of patients with HBV-related ACLF

and age

clinical stage

hepatic encephalopathy are independent risk factors that influencing the short-term survival rate.