Objective To explore the possible mechanism of Liangxue Tongyu Recipe（ 凉血通瘀方） in the treatment of cerebral hemorrhage. Methods A total of 108 SD rats were randomly divided into sham operation group

model group and Liangxue Tongyu group

with 36 rats in each group. All the rats except the sham operation group were treated with autologous blood injection to make cerebral hemorrhage rat model. After successful modeling

Liangxue Tongyu group was given 1. 3 ml/100 g Liangxue Tongyu Recipe Decoction（ concentration 1. 2 g/ml）

once a day for 5 days; The sham operation group and model group were given same amount of distilled water by gavage. The neurological scores and the intestinal motility of the rats were evaluated at 24 h

72 h and 120 h after intragastric administration. The expression of cholecystokinin-8（ CCK-8） in brain tissue and intestinal tissue was detected by immunohistochemistry. Brain tissue

intestinal tissue and serum CCK-8 contents were detected by enzyme-linked immuno sorbent assay（ ELISA）. Results Compared with the model group

the neurological scores of the rats in the Liangxue Tongyu group decreased at 72 h and 120 h（ P < 0. 05 or P < 0. 01）. Compared with the sham operation group

the number of black stools decreased and the percentage of black stools decreased at 6 h in the model group（ P < 0. 05 or P < 0. 01）

while the percentage of black stool in the Liangxue Tongyu group was increased when compared with that in the model group（ P < 0. 01）. Compared with the model group

the expression of CCK-8 in the brain tissue of Liangxue Tongyu group increased at 72 h and 120 h

and the expression of CCK-8 in intestinal tissue increased at 24 h（ P < 0. 05 or P < 0. 01）. The serum CCK-8 content of the rats in the Liangxue Tongyu group was decreased when compared with that in the sham operation group and the model group（ P < 0. 01）. Conclusion Liangxue Tongyu Recipe can improve neurological deficits

increase gastrointestinal motility and promote defecation in rats with cerebral hemorrhage

which may be related to increasing CCK-8 expression in intestinal tissue and brain tissue and decreasing serum CCK-8 content.