Objective To observe the effects of Sanqi Xueshangning Capsule（三七血伤宁胶囊） on traumatic response and clinical healing of patients treated with modified radical mastectomy. Methods Forty-one patients treated with modified radical mastectomy were randomly divided into 2 groups. Among them

26 cases in the control group were treated with conventional therapy

and 15 cases in the treatment group were additionally given Sanqi Xueshangning Capsule 6 h after operation

0. 4 g each time

3 times a day. The levels of inflammatory factors tumor necrosis factor-α（TNF-α） and interleukin-8（IL-8） in the drainage fluid were measured at 12 h

24 h

36 h

and 48 h post-operatively; the daily drainage volume and wound healing were recorded from 1 st to 4 th day after surgery. Results The drainage volumes of the treatment group on the 3 rd and 4 th day after operation was lower than those in the control group（P < 0. 05）. The IL-8 contents in the drainage fluid of the treatment group was lower than those of the control group at 36 h and 48 h after operation（P < 0. 05）. Both groups peaked at 36 h after operation. The TNF-αlevels in the fluid of the treatment group was significantly lower than those of the control group at 36 h and 48 h after operation（P < 0. 01）. Both groups peaked at 24 h after operation. Conclusion Sanqi Xueshangning Capsule can alleviate the traumatic stress response after modified radical mastectomy and reduce the levels of IL-8 and TNF-α in the drainage fluid

thus reducing the post-operative wound drainage.