Clinical Efficacy of Yixin Huoxue Pills（益心活血丸） on Patients of Acute ST Segment Elevation Myocardial Infarction after Percutaneous Coronary Intervention with Qi and Yin Deficiency Syndrome and Its Effects on Cardiac Function

LI Junlong; JIN Zheng; PI Jianbin; CHU Qingmin; WU Wei

doi:10.13288/j.11-2166/r.2019.11.011

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Clinical Efficacy of Yixin Huoxue Pills（益心活血丸） on Patients of Acute ST Segment Elevation Myocardial Infarction after Percutaneous Coronary Intervention with Qi and Yin Deficiency Syndrome and Its Effects on Cardiac Function

更新时间：2021-11-10

- Clinical Efficacy of Yixin Huoxue Pills（益心活血丸） on Patients of Acute ST Segment Elevation Myocardial Infarction after Percutaneous Coronary Intervention with Qi and Yin Deficiency Syndrome and Its Effects on Cardiac Function
- Journal of Traditional Chinese Medicine Vol. 60, Issue 11, Pages: 949-953(2019)
- 作者机构：
  
  1. 广州中医药大学
  2. 广州中医药大学第一附属医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2019.11.011
  CLC： R259
- Published：2019
- 稿件说明：
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[1]李俊龙,金政,皮健彬,褚庆民,吴伟.益心活血丸对气阴两虚证急性ST段抬高型心肌梗死经皮冠状动脉介入术后患者临床疗效及心功能的影响[J].中医杂志,2019,60(11):949-953.

LI Junlong, JIN Zheng, PI Jianbin, et al. Clinical Efficacy of Yixin Huoxue Pills（益心活血丸） on Patients of Acute ST Segment Elevation Myocardial Infarction after Percutaneous Coronary Intervention with Qi and Yin Deficiency Syndrome and Its Effects on Cardiac Function[J]. Journal of Traditional Chinese Medicine2019, 60(11): 949-953.
[1]李俊龙,金政,皮健彬,褚庆民,吴伟.益心活血丸对气阴两虚证急性ST段抬高型心肌梗死经皮冠状动脉介入术后患者临床疗效及心功能的影响[J].中医杂志,2019,60(11):949-953. DOI： 10.13288/j.11-2166/r.2019.11.011.

LI Junlong, JIN Zheng, PI Jianbin, et al. Clinical Efficacy of Yixin Huoxue Pills（益心活血丸） on Patients of Acute ST Segment Elevation Myocardial Infarction after Percutaneous Coronary Intervention with Qi and Yin Deficiency Syndrome and Its Effects on Cardiac Function[J]. Journal of Traditional Chinese Medicine2019, 60(11): 949-953. DOI： 10.13288/j.11-2166/r.2019.11.011.

摘要

目的评价益心活血丸辅助治疗对气阴两虚证急性ST段抬高型心肌梗死（STEMI）并接受经皮冠状动脉介入术（PCI）的患者临床疗效及心功能的影响。方法将166例气阴两虚证STEMI并经PCI术后患者随机分为治疗组和对照组

每组83例。对照组PCI术后予西医基础治疗

治疗组在PCI术后西医治疗基础上加用益心活血丸口服30天

比较两组中医症状疗效、心电图疗效及治疗前后血清脂蛋白磷脂酶A

（Lp-PLA

）、氨基末端脑钠肽前体（NT-ProBNP）水平

心功能指标

临床终点指标及不良事件。结果治疗组心电图总有效率93. 98%

显著高于对照组的87. 95%（P

0. 05）。治疗组各中医症状有效率及总有效率均显著高于对照组（P

0. 05）。两组治疗后血清Lp-PLA

、NT-ProBNP、左室舒张末内径（LVEDD）水平均下降（P

0. 05）

左室射血分数（LVEF）、舒张早期与晚期流速比值（E/A）水平均上升（P

0. 05）。治疗后治疗组血清NT-ProBNP、Lp-PLA

低于对照组（P

0. 05）

LVEF高于对照组（P

0. 05）。治疗期间两组均未出现明显不良反应。结论益心活血丸辅助治疗能够明显改善气阴两虚证STEMI经PCI术后患者中医症状及心电图疗效

降低患者血清Lp-PLA

、NT-ProBNP水平

增加患者的LVEF水平改善心脏收缩功能

且安全性好。

Abstract

Objective To evaluate the clinical efficacy of Yixin Huoxue Pills（益心活血丸） on patients of acute ST segment elevation myocardial infarction（STEMI） after percutaneous coronary intervention（PCI） with qi and yin deficiency syndrome and its effects on cardiac function. Methods A total of 166 STEMI patients of qi and yin deficiency syndrome who received PCI were randomized into a treatment group and a control group

with 83 patients in each group. The control group received western medicine basic treatment after PCI

and the treatment group received oral administration of Yixin Huoxue Pills for 30 days on the basis of western medicine treatment. Chinese medicine symptom curative effect

electrocardiogram curative effect

lipoprotein-associated phospholipase A

（Lp-PLA

）

Nterminal pro-brain Natriuretic Peptide（NT-ProBNP）

cardiac parameters

clinical end points and adverse events were compared before and after treatment in both groups. Results The total effective rate of the electrocardiogram of the treatment group was 93. 98%

which was significantly higher than the control group（87. 95%）. The total effective rate of Chinese medicine syndrome of the treatment group was significantly higher than that of the control group（P

0. 05）. The Lp-PLA

NT-proBNP

left ventricular diastolic diameter（LVEDD） levels decreased significantly（P

0. 05） in both groups after 30 days of treatment and the left ventricular ejection fraction（LVEF）

peak flow rate ratio（E/A） increased（P

0. 05）. After treatment

NT-proBNP

Lp-PLA

of the treatment group were lower than the control group（P

0. 05）

and the LVEF was higher than control group（P

0. 05）. During the treatment period

both groups showed no significant adverse reactions. Conclusion Yixin Huoxue Pills can significantly improve the symptoms of Chinese medicine and electrocardiogram in patients with STEMI after PCI of qi and yin deficiency syndrome

reduce serum Lp-PLA

NT-ProBNP levels

increase LVEF levels in patients

improve systolic function

with good safety.

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