Objective To observe the effects of five elements music therapy on negative psychology and sleep quality in patients with middle and advanced tumors. Methods A total of 120 patients with middle and advanced tumors were randomly divided into a treatment group and a control group

with 60 cases in each group. The control group received routine care

and the treatment group was treated with five elements music therapy on the basis of routine care. Both groups were treated for 45 days. Zung self-anxiety scale（SAS）

Zung self-depression scale（SDS）and Pittsburgh sleep quality index scale（PSQI） were used for assessment before and after intervention. Results The scores of SAS

SDS and PSQI in both groups were significantly reduced than those before the intervention（P <0. 01）

and the SAS

SDS and PSQI scores in the treatment group（48. 74 ± 4. 42

47. 49 ± 4. 67

6. 59 ± 1. 17）were significantly lower than those in the control group（55. 61 ± 4. 25

56. 53 ± 4. 51

8. 25 ± 1. 22）（P < 0. 01）.Conclusion Five element music therapy can significantly improve the negative psychological status of patients with middle and advanced cancer and improve the quality of sleep.