Objective To analyze the clinical efficacy of Qingkailing Injection（清开灵注射液） for ischemic cerebrovascular diseases based on hospital information system（HIS） in real world.Methods The patients with ischemic cerebrovascular disease using Qingkailing Injection in the electronic medical database of 16 tertiary hospitals nationwide

and the patients who were diagnosed with ischemic cerebrovascular disease in the HIS database without using Qingkailing Injection were selected.They were 1∶1 matched to the control group according to the age ± 5 years and same gender.The treatment outcome was compared as the outcome index of the efficacy evaluation

and the univariate logistic regression

logistic regression with biased scores

and biased logistic regression with covariate adjustment were used to control 59 confounding factors with significant differences between the 2 groups

so that the results were closer to the clinical real world.Results There were 1320 patients in the Qingkailing Injection group and the control group.There was significant difference in the treatment outcome between the 2 groups（P<0.05）.The effective rate of the Qingkailing Injection group was higher than the control group.Logistic regression analysis was performed after weighting the score.The regression coefficient was 0.50344.The treatment outcome of the Qingkailing Injection group was better than that of the control group（P<0.01）.The regression coefficient was 0.70566（P<0.01） by weighted logistic regression analysis with propensity scores with covariates.Conclusion Based on the real world data of HIS

Qingkailing Injection can improve the therapeutic effects of ischemic cerebrovascular disease and improve the treatment outcome in patients with ischemic cerebrovascular disease.