Objective To investigate the influencing factors of suspected allergic reaction of Tanreqing Injection（ 痰热清注射液）

to provide references for allergic reaction monitoring of Tanreqing Injection. Methods A total of175 patients with suspected allergic reactions during June 2015 to August 2018 in 7 hospitals were screened by prescription sequence analysis. According to the inclusion criteria of the control group

700 patients were matched with the control group by the trend value matching method according to the age

gender and hospitalization department.Conditional logistic regression was used to analyze the effects of vehicle

allergy history

single dose

and combination therapy on suspected allergic reactions. Results The vehicle

allergic history and single dose had no effects on the suspected allergic reaction of Tanreqing Injection（ P > 0. 05）. The 9 combination drugs of Tanreqing Injection increased the risk of suspected allergic reaction of Tanreqing Injection

including metoclopramide（ OR = 3. 499

P =0. 0005）

montelukast sodium（ OR = 3. 283

P = 0. 0009）

sodium bicarbonate（ OR = 3. 557

P = 0. 0009）

hemagglutinase（ OR = 3. 749

P = 0. 0013）

budesonide（ OR = 2. 778

P = 0. 0026）

pantoprazole（ OR = 2. 152

P =0. 0081）

penicillin（ OR = 2. 388

P = 0. 0131）

Potassium Sodium Dehydroandro（ OR = 2. 803

P = 0. 0131） and moxifloxacin（ OR = 1. 848

P = 0. 0404）. There were significant differences in blood calcium

serum sodium

neutrophil and white blood cell count between the control group and the suspected allergy group（ P < 0. 05）.Conclusion The suspected allergic reaction with Tanreqing Injection may be related to the above 9 drugs for combination use

as well as blood calcium

blood sodium and other blood indicators

but the results of the analysis still need further prospective studies.