Objective To investigate action mechanism of effective constituent Renshen（ Radix Ginseng） and Chuanxiong（ Rhizoma Ligustici Chuanxiong） drug pair in anti-atherosclerosis. Methods The chemical constituents of total saponins of panax ginseng and ligustrazine were searched in PubMed

Chinese National Knowledge Infrastructure（ CNKI）

traditional Chinese medicine system pharmacology database and analysis platform（ TCMSP database）to construct a chemical composition database. The component targets and disease targets were predicted through the BATMAN-TCM platform. Cytoscape 3. 6. 1 software was used for core target screening

GO gene and KEGG pathway enrichment analysis

and a network map of drug component target metabolic pathways was constructed to explore its action mechanism of anti-atherosclerosis. Results In this study

17 chemical components were collected

and the target component of the screening PPI network had 464 nodes and 214 832 connections. There are 17 core targets for drug diseases. The analysis of GO gene enrichment suggested two aspects of biological processes and molecular functions. The KEGG pathway enrichment analysis has potential regulatory pathways including PPAR pathway

adipocytokine signaling pathway and bile acid secretion

and explored that multiple of targets and pathways were intersect with obesity

and the PPARγ/PGC-1α/UCP1 signaling pathway can exert an anti-atherosclerotic effect by promoting browning of white fat. Conclusion The effective constituent Renshen（ Radix Ginseng） and Chuanxiong（ Rhizoma Ligustici Chuanxiong） can improve atherosclerosis through PPARγ/PGC-1α/UCP1 signaling pathway promoting browning of white fat.