Clinical Observation on the Effects of Changning Recipe（肠宁方） in the Treatment of 35 Cases of Diarrheatype Irritable Bowel Syndrome of Liver Stagnation and Spleen Deficiency Pattern

WENG Mianwei; CHEN Yibin; CAO Jian

doi:10.13288/j.11-2166/r.2019.19.010

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Clinical Observation on the Effects of Changning Recipe（肠宁方） in the Treatment of 35 Cases of Diarrheatype Irritable Bowel Syndrome of Liver Stagnation and Spleen Deficiency Pattern

更新时间：2021-11-10

- Clinical Observation on the Effects of Changning Recipe（肠宁方） in the Treatment of 35 Cases of Diarrheatype Irritable Bowel Syndrome of Liver Stagnation and Spleen Deficiency Pattern
- Journal of Traditional Chinese Medicine Vol. 60, Issue 19, Pages: 1663-1667(2019)
- 作者机构：
  
  1. 中山市人民医院
  2. 福建省厦门市中医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2019.19.010
  CLC： R259
- Published：2019
- 稿件说明：
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[1]翁棉伟,陈一斌,曹健.肠宁方治疗腹泻型肠易激综合征肝郁脾虚证35例临床观察[J].中医杂志,2019,60(19):1663-1667.

WENG Mianwei, CHEN Yibin, CAO Jian. Clinical Observation on the Effects of Changning Recipe（肠宁方） in the Treatment of 35 Cases of Diarrheatype Irritable Bowel Syndrome of Liver Stagnation and Spleen Deficiency Pattern[J]. Journal of Traditional Chinese Medicine2019, 60(19): 1663-1667.
[1]翁棉伟,陈一斌,曹健.肠宁方治疗腹泻型肠易激综合征肝郁脾虚证35例临床观察[J].中医杂志,2019,60(19):1663-1667. DOI： 10.13288/j.11-2166/r.2019.19.010.

WENG Mianwei, CHEN Yibin, CAO Jian. Clinical Observation on the Effects of Changning Recipe（肠宁方） in the Treatment of 35 Cases of Diarrheatype Irritable Bowel Syndrome of Liver Stagnation and Spleen Deficiency Pattern[J]. Journal of Traditional Chinese Medicine2019, 60(19): 1663-1667. DOI： 10.13288/j.11-2166/r.2019.19.010.

摘要

目的评价肠宁方治疗腹泻型肠易激综合征（IBS-D）肝郁脾虚证患者的临床疗效及安全性。方法将74例IBS-D患者随机分为治疗组和对照组各37例

治疗组予自拟肠宁方煎服治疗

每日1剂。对照组予匹维溴铵片每次50 mg

每日3次口服治疗

两组疗程均为4周。于治疗2周、4周后对腹痛及腹泻应答率进行评估;比较治疗前后肠易激综合征严重程度量表（IBS-SSS）积分及中医证候积分

并判定IBS-SSS疗效及中医证候疗效;观察治疗前后安全性指标

记录不良事件。结果治疗4周治疗组患者腹泻应答率（77. 14%）及腹痛应答率（82. 86%）均明显高于对照组（分别为54. 55%及60. 61%）（P <0. 05）。治疗组治疗4周后IBS-SSS总有效率（82. 86%）高于对照组（60. 61%）（P <0. 05）。中医证候疗效治疗组总有效率（88. 57%）高于对照组（60. 61%）（P <0. 01）。两组患者治疗后腹泻、腹痛、急躁易怒、两胁胀满、纳呆食少、腹胀、肠鸣的单项积分较治疗前均明显下降（P <0. 05）

治疗组患者治疗后腹痛、腹泻及急躁易怒积分明显低于对照组（P <0. 05）。两组患者安全指标治疗后均未见明显改变。结论肠宁方治疗IBS-D肝郁脾虚证疗效优于匹维溴铵片

可有效缓解腹痛、腹泻症状

改善患者整体病情及肝郁脾虚证候

安全性好。

Abstract

Objective To evaluate the clinical efficacy and safety of Changning Recipe（肠宁方） in the treatment of diarrhea-type irritable bowel syndrome（ IBS-D） of liver stagnation and spleen deficiency pattern. Methods A total of 74 patients with IBS-D were randomly divided into a treatment group and a control group

with 37 cases in each group. The treatment group was treated with self-made Changning Recipe

1 dose per day. The control group received oral administration of Pivaviron tablets 50 mg each time

3 times a day for 4 weeks. The response rates of abdominal pain and diarrhea were evaluated after 2 weeks and 4 weeks of treatment. The IBS-SSS scores and traditional Chinese medicine（ TCM） syndrome scores were compared before and after treatment

and the efficacy of TCM syndrome and IBS-SSS were determined. The safety indicators before and after treatment were observed

and the adverse events were recorded. Results The diarrhea response rate（ 77. 14%） and abdominal pain response rate（ 82. 86%） in the treatment group were significantly higher than those in the control group（ 54. 55% and 60. 61%

respectively）（ P < 0. 05）. The total effective rate of IBS-SSS（ 82. 86%） in the treatment group after 4 weeks of treatment was higher than that in the control group（ 60. 61%）（ P < 0. 05）. The total effective rate of the TCM syndrome treatment group（ 88. 57%） was higher than that of the control group（ 60. 61%）（ P < 0. 01）. The single symptom scores of diarrhea

abdominal pain

irritability

distention and fullness in both sides of the chest

poor appetite

bloating

and borborygmus were significantly decreased in both groups after treatment（ P < 0. 05）. The scores of abdominal pain

diarrhea and irritability in the treatment group was significantly lower than that of the control group（ P < 0. 05）. There was no significant change in the safety indicators of both groups after treatment. Conclusion Changning Recipe is better than Pivobium bromide in the treatment of IBS-D of liver stagnation and spleen deficiency pattern. It can effectively relieve the symptoms of abdominal pain and diarrhea

improve the overall condition of patients and liver stagnation and spleen deficiency syndrome

and has good safety.

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