This paper introduced ZHANG Lei’s experience in treating motor neuron disease. This paper applied the thought of "analyzing the syndrome to figure out the reason". And it summarized that the etiology and pathogenesis of motor neuron disease were damp-heat and amassing poison

combined internal and external pathogens

windphlegm obstructing collaterals

intermingling of turbid and blood stasis and five zang-organs deficiency and failure of vital energy. By differentiating the nature of dampness

stasis

phlegm and wind

the disease location of zang-fu meridians and collaterals

and the relationship between pathogenic qi and vital qi of deficiency

excess

rising and falling. The disease was divided into six syndrome patterns

i. e. damp-turbidity immersion sinews

wind-phlegm obstructing collaterals

intermingling of turbid and blood stasis

static heat obstruction

spleen deficiency with toxin accumulation and liver and kidney deficiency.