Objective To evaluate the efficacy and safety of Compound Danshen Dripping Pills（ 复方丹参滴丸）combined with western medicine in the treatment of unstable angina pectoris（ UAP）. Methods China National Knowledge Infrastructure

VIP Chinese Journal Database

Wanfang Digital Journal Full-text Database

China Biomedical Literature Database

Embase

PubMed

Cochrane Library were retrieved to collect randomized controlled trials of Compound Danshen Dripping Pills for UAP. The search time was from database begining to May 31

2019. The methodological quality of the included studies was assessed using a bias risk assessment scale. Meta-analysis of outcome measures including cardiovascular events

angina pectoris

high-sensitivity C-reactive protein（ hs-CRP）

electrocardiogram efficacy

duration of angina pectoris

and adverse event rates was performed by using RevMan 5. 3 software

and according to GRADE criteria

an evaluation of the quality of the evidence was conducted. Results A total of 43 randomized controlled trials involving 4545 patients were included. Meta-analysis showed that the Compound Danshen Dripping Pills combined with western medicine conventional treatment more significantly reduced the incidence of cardiovascular events within 6 months [RR = 0. 47

95% CI（ 0. 26

0. 83）

P = 0. 010]

reduced angina attacks [SMD =-2. 43

95% CI（-3. 66

-1. 20）

P = 0. 001]

reduced hs-CRP [SMD =-1. 70

95% CI（-2. 79

-0. 61）)

P = 0. 002]

improved ECG efficacy [RR = 1. 31

95% CI（ 1. 25

1. 37）

P < 0. 001]

shortened angina duration [MD =-2. 97

95% CI（-4. 09

-1. 85）

P < 0. 001]; and the incidence of adverse events was lower [RR = 0. 71

95% CI（ 0. 54

0. 93）

P = 0. 01] as compared with simple use western medicine conventional treatment. According to the GRADE criteria

the 4 outcome measures of cardiovascular event rate

hsCRP

ECG efficacy

and adverse event rate were low-quality evidence

and the number of angina attacks and angina duration were extremely low-quality evidence. Conclusion The effect of Compound Danshen Dripping Pills combined with conventional western medicine in treating UAP is better than that of conventional western medicine alone.The adverse reactions are few

but the quality of the research is low. More well-designed multi-center controlled trials are needed to increase the intensity of evidence.