Objective To explore the possible action mechanism of Wenxin Granules（ 稳心颗粒） in the treatment of ventricular tachycardia（ VT） after myocardial infarction. Methods A rat model of myocardial infarction was established by ligating the left anterior descending coronary artery in rats. A total of 32 successful rat models were randomly divided into a model group

a virus interference group

an amiodarone group and a Wenxin Granules group. A normal group（ feed normally）

sham operation group（ only threaded without ligation） were set up

with 8 rats in each group. In the virus interfering group

2 × 10

10

pfu E6-related protein（ E6AP） was used to interfere with adenovirus on the 1 st and 7 th day after operation. The amiodarone group was intraperitoneally injected with 2. 5 mg/kg amiodarone injection on the 2 nd day after operation

2 times a day; Wenxin Granules were given to the Wenxin Granules group at a dose of 1. 62 g/kg each time to make an equal volume of 2 ml of the suspension; The remaining groups were given 2 ml of distilled water 2 times a day for 7 days. Seven days later

VT was induced by intravenous bolus injection of strontium chloride 0. 4 mg/kg

and the time and duration of VT from the administration of strontium chloride were recorded. RT-PCR and immunohistochemistry were used to detect E6AP

CCAAT or enhancer binding protein alpha（ C/EBPα） mRNA and protein expression in each group. Results Compared with the normal group and the sham operation group

the VT appearance time of the model group shortened

the duration prolonged

the expression of E6 AP mRNA and protein decreased

and the expression of C/EBPα mRNA and protein increased（ P

<

0. 05）. Compared with the model group

the time of VT in the virus interfering group shortened

the duration prolonged

the expression of E6AP mRNA and protein decreased

and the expression of C/EBPα mRNA and protein increased（ P

<

0. 05）. The amiodarone group and the Wenxin Granules group could delay the VT appearance time

reduce the duration

significantly increase the expression of E6AP mRNA and protein

and significantly reduce the expression of C/EBP mRNA and protein（ P

<

0. 05）. There was no significant difference between the amiodarone group and the Wenxin Granules group（ P

>

0. 05）. Conclusion Wenxin Granules may increase the expression of E6AP and inhibit the expression of C/EBPα in myocardial tissue after myocardial infarction

thereby increasing the threshold and decreasing duration of VT after myocardial infarction.