Objective To study the characteristics of traditional Chinese medicine（TCM） syndromes in Parkinson’s disease patients with sleep disorders. Methods A total of 156 patients with Parkinson’s disease were divided into a sleep disorder group（105 cases） and a non-sleep disorder group（51 cases） by Parkinson’s Disease Sleep Disorder Scale

and the Parkinson’s disease syndrome element scale developed by the research group was used to identify syndrome elements

including 13 TCM syndrome elements such as kidney deficiency

spleen deficiency

qi deficiency

blood deficiency

yin deficiency

yang deficiency

marrow reduction

blood stasis

yang hyperactivity

internal heat

phlegm turbid

qi stagnation and liver wind. The differences between the scores of the syndrome elements and the proportion

and the composite syndrome elements were compared between groups. The logistic regression method was further used to analyze the risk of the syndrome elements in the pathogenesis of Parkinson’s disease. Results In the sleep disorder group

yin deficiency accounted for 85. 7%

marrow reduction accounted for 87. 6%

and those in the non-sleep disorder group was 70. 6% and 66. 7%

respectively. The difference was statistically significant（P =0. 031

P = 0. 004）; In the sleep deficiency group

the kidney deficiency syndrome elements score was（10. 62 ±3. 46） points

and that of the non-sleep disorder group was（9. 04 ± 3. 43） points. The difference was statistically significant（P = 0. 012）. The proportion of yin deficiency + yang hyperactivity

kidney deficiency + marrow reduction and yin deficiency + marrow reduction in the sleep disorder group was 63. 8%

81. 9%

and 77. 1%

respectively

which was significantly higher than 45. 1%

58. 8%

47. 1% in the non-sleep disorder group. The difference had statistical significance（P = 0. 038

P = 0. 003

P < 0. 001）. Yin deficiency（P = 0. 027

OR = 2. 500） and marrow reduction（P = 0. 003

OR = 3. 538） syndrome elements had risks for the onset of sleep disorders in Parkinson’ s disease; Yin deficiency + yang hyperactivity（P = 0. 028

OR = 2. 146）

kidney deficiency + marrow reduction（P =0. 002

OR = 3. 168） and yin deficiency + marrow reduction（P < 0. 001

OR = 3. 797） had risks for the onset of sleep disorder in Parkinson’s disease. Conclusion The main syndromes of sleep disorders in Parkinson’ s disease are yin deficiency and marrow reduction. They often appear as complex syndromes of yin deficiency and yang hyperactivity

kidney deficiency and marrow reduction

which has risks for the onset of sleep disorders in Parkinson’ s disease.