Objective To explore the distribution of traditional Chinese medicine（TCM） syndromes in perimenopausal syndrome and the medication rule of Chinese materia medica. Methods Chinese National Knowledge Infrastructure（CNKI） and PubMed were searched for clinical research on Chinese medicine or integrative Chinese and western medicine in the treatment of perimenopausal syndrome. Literature published time was from March 1

2008 to March 31

2019. The syndromes

syndrome elements and drug information included in the research literature were extracted to establish a database

and the types of syndromes

syndrome elements

drug and drug categories were statistically analyzed

and the distribution of commonly used drugs in the prescriptions was visually analyzed. Results A total of 345 articles were included. There were 116 syndrome types. The top 3 syndrome types of high frequency were kidney yin deficiency（209）

liver qi stagnation（164）

and liver and kidney yin deficiency（105）. There were5 disease location syndrome elements. Specifically

frequency distribution was kidney（798）

liver（404）

heart（148）

spleen（118）

and lung（3）; there were 10 disease nature syndrome elements. The top 3 high frequency elements were yin deficiency（317）

qi deficiency（161）

and qi stagnation（115）. Totally 109 kinds of Chinese materia medica were used

involving 17 categories. The top 3 Chinese materia medica with high frequency were Radix Rehmanniae Preparata（169）

Fructus Corni（141） and Radix Paeoniae Alba（134）. The top 3 categories were deficiency-tonifying herbs（1658）

heat-clearing herbs（458）

and interior-warming herbs（278）. Conclusion Perimenopausal syndrome is characterized by intermingled deficiency and excess

mainly with deficiency syndrome.The main lesions are located in the kidney

liver and heart. Deficiency-tonifying herbs

heat-clearing herbs

interiorwarming herbs are often used for treatment.