Objective To explore the characteristics of traditional Chinese medicine（ TCM） syndromes in different age of postmenopausal women with reduced bone mass

and to provide a theoretical basis for the prevention of osteoporosis by TCM. Methods A questionnaire for osteoporosis research was developed

and the clinical data of1419 postmenopausal women with reduced bone mass was collected. TCM syndrome differentiation was performed for patients of different ages（ 41-59 years old

60-69 years old

70-85 years old）. The syndrome differentiation of deficiency syndrome was divided into liver deficiency

heart deficiency

spleen deficiency

lung deficiency

kidney deficiency

qi deficiency and blood deficiency syndrome. Common syndrome types were kidney deficiency and blood stasis

liver and kidney yin deficiency

kidney yang deficiency

spleen and stomach weakness

spleen and kidney yang deficiency

and kidney yin deficiency. The distribution of body mass index（ BMI）

bone mineral density of lumbar vertebrae

greater trochanter

and femoral neck

main symptoms

deficiency syndrome

and common syndromes were compared between different age groups. Results There were 549 patients aged 41-59 years

679 patients aged 60-69 years

and 191 patients aged 70-85 years. The difference of BMI in each group was statistically significant（ P < 0. 05）. Compared with 41-59 years old patients

the bone density of lumbar vertebrae and femoral neck decreased in patients aged 60-69 years. The bone density of the greater trochanter and femoral neck of 70-85 years old patients also decreased（ P < 0. 05）. Compared with 60-69 years old

the bone density of the greater trochanter and femoral neck was decreased in patients aged 70-85 years（ P < 0. 05）. The first symptom was forgetfulness in all groups. The proportion of kidney deficiency and liver deficiency in the 3 groups ranked the top two

and the proportion of heart deficiency and spleen deficiency was also higher

and the proportion of qi deficiency and blood deficiency was lower. With the increase of age

the proportion of liver and kidney yin deficiency syndrome and kidney yin deficiency syndrome was decreasing

and the proportion of kidney deficiency and blood stasis syndrome and kidney yang deficiency syndrome was rising. Conclusion Postmenopausal women with reduced bone mass are mainly composed of kidney deficiency and liver deficiency at different ages. With age increasing

kidney deficiency and blood stasis syndrome and kidney yang deficiency are obvious

and the overall syndrome type is not obviously changed.