Objective To investigate the cardio protective effect of Qiangxin Yihao Compound（强心一号复方） on septic mice and its possible mechanism. Methods A total of 45 C57 BL/6 mice were randomly divided into a sham operation group

a model group and a Qiangxin group

with 15 mice in each group. Cecal ligation and puncture（CLP） was used to establish sepsis model in the model group and the Qiangxin group. The Qiangxin group was given 1 g/（kg·d） Qiangxin Yihao Compound by gavage 2 hours after operation

and the model group and the sham operation group were given 1 ml normal saline by gavage

once for each group. Cardiac function including interventricular septal thickness（IVS）

left ventricular posterior wall systolic thickness（LVPWS）

left ventricular posterior wall diastolic thickness（LVPWD）

left ventricular end systolic diameter（LVEDS）

left ventricular end diastolic diameter（LVEDD） and left ventricular ejection fraction（LVEF） was assessed by small animal ultrasound 48 hours after operation. Cardiac pathological changes were assessed by HE and WGA staining. Realtime PCR was used to detect the mRNA expression of inflammatory cytokines including interleukin 6（IL-6）

tumor necrosis factor α（TNF-α） and interleukin 1β（IL-1β） in heart tissue. ELISA was used to evaluate the secretion of inflammatory cytokines in serum. Results Compared with the sham operation group

IVS and LVEF of the model group decreased significantly（P<0.05）

and IL-1β

TNF-α and IL-6 mRNA expression in cardiac tissue and IL-1 a

TNF-α and IL-6 protein levels in the serum were increased significantly（P<0.05）. Compared with the model group

IVS and LVEF of the Qiangxin group were significantly increased

and IL-1β

TNF-α and IL-6 mRNA expression in cardiac tissue and IL-1β

TNF-α and IL-6 protein levels in the serum were decreased significantly（P<0.05）. Pathological results showed that compared with the sham operation group

the inflammatory cell infiltration of cardiac tissue increased and the cardiomyocytes compensatory hypertrophy in the model group; compared with the model group

the inflammatory cell infiltration and cardiomyocyte hypertrophy in the cardiac group were improved. Conclusion Qiangxin Yihao Compound has protective effects on cardiac function and cardiac myocytes remodeling in CLP mice

and its mechanism may be related to the alleviation of inflammatory responses.