Clinical Observation on Bushen Qishu Qiangxin Granules （补肾启枢强心颗粒） in the Treatment of 40 Cases of Chronic Heart Failure of Heart and Kidney Yang Deficiency Type

HU Fang; SHEN Jinfeng; DENG Peng; CHEN Hongtao; LIU Zhongyong

doi:10.13288/j.11-2166/r.2020.01.011

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Clinical Observation on Bushen Qishu Qiangxin Granules （补肾启枢强心颗粒） in the Treatment of 40 Cases of Chronic Heart Failure of Heart and Kidney Yang Deficiency Type

更新时间：2021-11-10

- Clinical Observation on Bushen Qishu Qiangxin Granules （补肾启枢强心颗粒） in the Treatment of 40 Cases of Chronic Heart Failure of Heart and Kidney Yang Deficiency Type
- Journal of Traditional Chinese Medicine Vol. 61, Issue 1, Pages: 48-52(2020)
- 作者机构：
  
  1. 江西中医药大学
  2. 浙江省温岭市第一人民医院
  3. 江西中医药大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.13288/j.11-2166/r.2020.01.011
  CLC： R259
- Published：2020
- 稿件说明：
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[1]胡芳,沈金峰,邓鹏,陈洪涛,刘中勇.补肾启枢强心颗粒辅助治疗心肾阳虚型慢性心力衰竭40例临床观察[J].中医杂志,2020,61(01):48-52.

HU Fang, SHEN Jinfeng, DENG Peng, et al. Clinical Observation on Bushen Qishu Qiangxin Granules （补肾启枢强心颗粒） in the Treatment of 40 Cases of Chronic Heart Failure of Heart and Kidney Yang Deficiency Type[J]. Journal of Traditional Chinese Medicine2020, 61(1): 48-52.
[1]胡芳,沈金峰,邓鹏,陈洪涛,刘中勇.补肾启枢强心颗粒辅助治疗心肾阳虚型慢性心力衰竭40例临床观察[J].中医杂志,2020,61(01):48-52. DOI： 10.13288/j.11-2166/r.2020.01.011.

HU Fang, SHEN Jinfeng, DENG Peng, et al. Clinical Observation on Bushen Qishu Qiangxin Granules （补肾启枢强心颗粒） in the Treatment of 40 Cases of Chronic Heart Failure of Heart and Kidney Yang Deficiency Type[J]. Journal of Traditional Chinese Medicine2020, 61(1): 48-52. DOI： 10.13288/j.11-2166/r.2020.01.011.

摘要

目的观察补肾启枢强心颗粒辅助西药治疗对心肾阳虚型慢性心力衰竭患者微炎症的影响。方法选取心肾阳虚型慢性心力衰竭患者80例

随机分为治疗组和对照组各40例。对照组患者给予西药常规治疗

治疗组患者在常规治疗基础上口服补肾启枢强心颗粒

每日1剂

早晚分服

两组疗程均为8周。对患者微炎症指标超敏C反应蛋白（hs-CRP）与反映心功能的指标N末端B型利钠肽原（NT-proBNP）的相关性进行分析。评估两组治疗前后中医症状评分

检测两组患者治疗前后微炎症指标[hs-CRP、肿瘤坏死因子α（TNF-α）、白细胞介素6（IL-6）]及NT-proBNP、左心室射血分数（LVEF）、舒张早期最大流速（E峰）/舒张晚期最大流速（A峰）（E/A）。结果心肾阳虚型慢性心力衰竭患者hs-CRP与NT-proBNP水平呈正相关关系（r=0.79）。两组患者治疗后中医症状评分均明显下降

与对照组比较

治疗组降低更明显（P<0.05）。两组均可改善微炎症状态

与对照组比较

治疗组TNF-α、IL-6、hs-CRP水平降低更明显（P<0.05）。两组均可以降低NT-proBNP及提高LVEF、E/A

与对照组比较

治疗组NT-proBNP降低及LVEF、E/A升高水平更明显（P<0.05）。结论补肾启枢强心颗粒能在一定程度上抑制心肾阳虚型慢性心力衰竭患者微炎症水平

从而改善患者心功能及临床症状。

Abstract

Objective To observe the effects of Bushen Qishu Qiangxin Granules（补肾启枢强心颗粒） adjuvant with western medicine on microinflammation in chronic heart failure patients with heart and kidney yang deficiency. Methods A total of 80 chronic heart failure patients with heart and kidney yang deficiency were selected and randomly divided into a treatment group and a control group

with 40 cases in each group. The patients in the control group were given conventional western medicine treatment. The patients in the treatment group were added with Bushen Qishu Qiangxin Granules on the basis of routine treatment

one dose per day

taking in the morning and evening. Both groups were treated for 8 weeks. The correlation between the patient′s microinflammation index hypersensitive C-reactive protein（hs-CRP） and the N-terminal pro-B-type natriuretic peptide（NT-proBNP）

which reflects cardiac function was analyzed. Traditional Chinese medicine symptom scores before and after treatment were evaluated in the 2 groups

and micro-inflammatory indexes including hs-CRP

tumor necrosis factor alpha（TNF-α）

interleukin 6（IL-6） and heart function indexes such as NT-proBNP

and left ventricle ejection fraction（LVEF）

early diastolic maximum flow（E peak）/late diastolic maximum flow（A peak）（E/A）. Results Level of hs-CRP was positively correlated with NT-proBNP（r=0.79）. Traditional Chinese medicine symptom scores of both groups were significantly decreased after treatment. Compared with the control group

the treatment group had a more significant decrease（P<0.05）. Both groups can improve the micro-inflammatory state. Compared with the control group

the levels of TNF-α

IL-6 and hs-CRP in the treatment group were significantly reduced（P<0.05）. Both groups can reduce NT-proBNP and increase LVEF and E/A. Compared with the control group

the NT-proBNP reduction and LVEF and E/A increase in the treatment group were more significant（P<0.05）. Conclusion Bushen Qishu Qiangxin Granules may inhibit the level of microinflammation in patients with chronic heart failure with heart and kidney yang deficiency and improve the heart function and clinical symptoms.

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