Objective To explore the influencing factors related to the risk of carcinogenesis of chronic atrophic gastritis. Methods A total of 180 patients with chronic atrophic gastritis diagnosed by gastroscopy and pathology were collected

and the general information

traditional Chinese medicine（TCM） symptoms

staging of cancer risk of operative link for gastritis assessment（OLGA）/operative link gastritis intestinal metaplasia assessment（OLGIM）（OLGA/OLGIM） related to the risk of gastric cancer were collected through the four diagnosis of TCM. Firstly

univariate correlation analysis was carried out to explore the correlation between gender

age

history of helicobacter pylori（Hp） infection

education

body mass index（BMI）

smoking history

drinking history

family cancer history

TCM symptoms

TCM syndrome types and OLGA

OLGIM risk stage. Further analysis of independent risk factors was performed by using binary logistic regression. Results Univariate correlation analysis showed that Hp infection history

family cancer history

and TCM syndrome types were related to OLGA stage（P=0.013

P=0.010

P=0.006）; Hp infection history was related to OLGIM stage（P=0.01）. Binary Logistic regression analysis showed that the history of Hp infection（OR=2.365

95% CI: 1.055～5.302

P=0.037） and syndrome of blood stasis in the stomach（OR = 9.972

95% CI: 1.637～60.743

P=0.013） could affect OLGA stage; Hp infection history can affect OLGIM stage（OR = 3.017

95% CI: 1.541～5.909

P=0.001）. Conclusion The history of Hp infection and TCM syndrome types are associated with an increased risk of canceration in patients with chronic atrophic gastritis. Among them

the risk of cancer of syndrome of blood stasis in the stomach is high.