Objective To investigate the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of novel coronavirus pneumonia（COVID-19） by retrospectively analyzing the clinical records of 52 patients. Methods The data of patients with COVID-19 from Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine during January 15 th

2020 to February 8 th

2020 were collected to investigate and analyze the basic information

traditional Chinese medical syndromes

laboratory tests and treatment methods. Patients were divided into two groups according to the intervention

a western medicine group of 18 cases treated with anti-virus

anti-infection and auxiliary supportive drugs

and an integrated treatment group of 34 cases treated with traditional Chinese medicine decoctions

patent Chinese medicines and traditional Chinese medicine injections in addition to the western medicine group. Clinical symptoms disappearance time

body temperature normalization time

accompanying symptom disappearance rate

average hospitalization days

clinical cure rate

and mortality rate were compared between groups. Results The 52 patients include 23 male patients and 29 female patients

the average age was（54.00±12.83） years old

and the time from onset to hospitalization was（7.44 ± 2.99） days. The main symptoms include fever（75%）

fatigue（61.5%）

cough（50%）

and other symptoms（34.6%）. According to the conditions at the time of admission

there were 76.9% ordinary type

19.2% severe patients

and 3.8% critical patients. The main syndrome types in Chinese medicine were dampness-toxin stagnated in the lung（30.8%）

pestilence-toxicity blocking the lung（25.0%）

damp-heat accumulation toxin in the lung（21.2%）

pathogenic heat congesting in the lung（19.2%） and internal blockade and external collapse（3.8%）. Laboratory testing showed the following results: lymphocytes percentage（18.53±11.01） %

serum amyloid A（111.65±76.98） mg/L

C-reaction protein（31.34±21.99） mg/L and erythrocyte sedimentation rate（22.60±15.65） mm/H. The clinical symptom disappearance time [（5.15±1.68） d]

body temperature recovery time [（2.64±1.31） d]

average hospitalization days [（7.38±2.06） d]

and Chinese medicine syndrome scale score [（13.29±3.79） points] of the integrated treatment group were significantly lower than those in the western medicine group（P<0.05 or P<0.01）. When patients were discharged from hospital

the accompanying symptom disappearance rate（87.9%）

the clinical cure rate（91.2%）

and the incidence of common type patients developed to severe type（5.9%） in the integrated treatment group were significantly superior to those in the western medicine group（the corresponding results 38.9%

61.1%

and 33.3% respectively

P<0.05 or P<0.01）. Conclusion The treatment of integrated Chinese and western medicine can significantly alleviate the clinical symptoms

shorten the course of disease and improve the cure rate

showing advantage to single use western medicine

which is worthy of clinical promotion and application.