The theory of "harmful hyperactivity and responding inhibition" is an important rule for traditional Chinese medicine（TCM） to understand the physiological and pathological imbalance of human body and to guide the use of drugs. This theory could summarize the physiological virtuous cycle of "hyperactivity and self-control to avoid harm" between glycolipid and islet β cells

and could also clarify the pathological vicious circle of islet β cell injury under glycolipid toxicity. It coincides with the ceRNA network of "lncRNA/circRNA restricting miRNA

miRNAs restricting mRNA

lncRNA/circRNA Promoting mRNA". Under the guidance of this understanding

type 2 diabetes can be treated with the idea of dispelling pathogenic factor to control hyperactivity

and supporting the vital qi to control harm for clinical treatment and scientific research.